ArticleClinical endoscopy2019
Factors Associated with Malignant Biliary Strictures in Patients with Atypical or Suspicious Cells on Brush Cytology.
Article in Clinical endoscopy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04112030 (Role of Digital Image Analysis in Diagnosing Nature of Indeterminate Biliary Duct Stricture), which is not on this map. Cited by 7 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Role of Digital Image Analysis in Diagnosing Nature of Indeterminate Biliary Duct Stricture
Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.
- Risk of Malignancy for Indeterminate Cytology of Bile Duct Strictures: A Systematic Review and Meta-analysis.Annals of surgical oncology · 2025Pooled it
- Clinical outcomes of endoscopic retrograde cholangiopancreatography after Billroth II anastomosis: a comparison of gastroscope and duodenoscope.BMC gastroenterology · 2025Article
- High Diagnostic Yield of Endoscopic Retrograde Cholangiopancreatography Brush Cytology for Indeterminate Strictures.Journal of the Canadian Association of Gastroenterology · 2022Article
- Tips and tricks for the diagnosis and management of biliary stenosis-state of the art review.World journal of gastrointestinal endoscopy · 2021Review
- Predicting Malignancy of Biliary Stricture with a Nomogram in Patients with a Non-Malignant Endoscopic Tissue Diagnosis: A Retrospective Study.Cancer management and research · 2021Article
- How Can We Differentiate Malignant Biliary Strictures from Clinically Indeterminate Biliary Strictures?Clinical endoscopy · 2019Article
- Digital Image Analysis has an Additive Beneficial Role to Conventional Cytology in Diagnosing the Nature of Biliary Ducts Stricture.Journal of clinical and experimental hepatologyArticle
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
aimsPathological diagnosis of biliary strictures with atypical or suspicious cells on endoscopic retrograde brush cytology and indeterminate strictures on imaging is challenging. The aim of this study was to identify markers for malignant strictures in such cases.
methodsWe retrospectively analyzed data collected from 146 consecutive patients with indeterminate biliary strictures on imaging who underwent endoscopic retrograde brush cytology from 2007 to 2013. Factors associated with malignant strictures in patients with atypical or suspicious cells on brush cytology were identified.
resultsAmong the 67 patients with a malignant disease (48 cholangiocarcinoma, 6 gallbladder cancer, 5 pancreatic cancer, 5 ampulla of Vater cancer, and 3 other types), 36 (53.7%) had atypical or suspicious cells on brush cytology. Among these, the factors that independently correlated with malignant strictures were stricture length (odds ratio [OR], 5.259; 95% confidence interval [CI], 1.802- 15.294) and elevated carbohydrate antigen 19-9 (CA19-9) (OR, 3.492; 95% CI, 1.242-9.815), carcinoembryonic antigen (CEA) (OR, 4.909; 95% CI, 1.694-14.224), alkaline phosphatase (ALP) (OR, 3.362; 95% CI, 1.207-9.361), and gamma-glutamyl transpeptidase (rGT) (OR, 4.318; 95% CI, 1.512-12.262).
conclusionElevated levels of CA19-9, CEA, ALP, and rGT and stricture length are associated with malignant strictures in patients with indeterminate biliary strictures on imaging and atypical or suspicious cells on brush cytology.
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