ArticlePloS one2019
Assessment of intraductal carcinoma in situ (DCIS) using grating-based X-ray phase-contrast CT at conventional X-ray sources: An experimental ex-vivo study.
Article in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 25 citations in OpenAlex.
- Simultaneous signal optimization of refraction and attenuation in x-ray grating interferometry: A case study for breast imaging.Medical physics · 2025Article
- Comparison of three reconstruction algorithms for low-dose phase-contrast computed tomography of the breast with synchrotron radiation.Medical physics · 2025Article
- Grating-based x-ray dark-field mammography: Assessing complementary imaging information in simple cystic lesions and typical fibroadenoma.Medical physics · 2025Article
- Phase contrast micro-CT with adjustable in-slice spatial resolution at constant magnification.Physics in medicine and biology · 2024Article
- Integrating X-ray phase-contrast imaging and histology for comparative evaluation of breast tissue malignancies in virtual histology analysis.Scientific reports · 2024Article
- Mammographically detected breast clustered microcalcifications localized by chest thin-section computed tomography.World journal of surgical oncology · 2024Article
- Towards virtual histology with X-ray grating interferometry.Scientific reports · 2023Article
- Anatomical study of the red flour beetle using synchrotron radiation X-ray phase-contrast micro-tomography.Journal of anatomy · 2023Review
- Article
- Dedicated breast CT: state of the art-Part II. Clinical application and future outlook.European radiology · 2022Review
- Quantitative X-ray phase contrast computed tomography with grating interferometry : Biomedical applications of quantitative X-ray grating-based phase contrast computed tomography.European journal of nuclear medicine and molecular imaging · 2021Review
- Dose and spatial resolution analysis of grating-based phase-contrast mammography using an inverse Compton x-ray source.Journal of medical imaging (Bellingham, Wash.) · 2020Article
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Authors and funding
11 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe extent of intraductal carcinoma in situ (DCIS) is commonly underestimated due to the discontinuous growth and lack of microcalcifications. Specimen radiography has been established to reduce the rate of re-excision. However, the predictive value for margin assessment with conventional specimen radiography for DCIS is low. In this study we assessed the potential of grating-based phase-contrast computed tomography (GBPC-CT) at conventional X-ray sources for specimen tomography of DCIS containing samples. MATERIALS AND
methodsGBPC-CT was performed on four ex-vivo breast specimens containing DCIS and invasive carcinoma of non-specific type. Phase-contrast and absorption-based datasets were manually matched with corresponding histological slices as the standard of reference.
resultsMatching of CT images and histology was successful. GBPC-CT showed an improved soft tissue contrast compared to absorption-based images revealing more histological details in the same sections. Non-calcifying DCIS exceeding the invasive tumor could be correlated to areas of dilated bright ducts around the tumor.
conclusionsGBPC-CT imaging at conventional X-ray sources offers improved depiction quality for the imaging of breast tissue samples compared to absorption-based imaging, allows the identification of diagnostically relevant tissue details, and provides full three-dimensional assessment of sample margins.
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