ArticleCancer2019
Survival after a cancer diagnosis among solid organ transplant recipients in the United States.
Article in Cancer, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 3 of them syntheses that pooled it.
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Who cites it
45 citing papers in PubMed, 3 syntheses or guidelines pooled it, 94 citations in OpenAlex.
- Cancer-related mortality among solid organ transplant recipients: systematic review and meta-analysis.Frontiers in transplantation · 2026Pooled it
- Immune-related conditions and cancer-specific mortality among older adults with cancer in the United States.International journal of cancer · 2022Pooled it
- Cancer risk in heart or lung transplant recipients: A comprehensive analysis of 21 prospective cohorts.Cancer medicine · 2020Pooled it
- Long-Term Efficacy and Allograft Loss after Immune Checkpoint Inhibitor Therapy in Solid Organ Transplant Recipients with Advanced Cutaneous Squamous Cell Carcinoma.medRxiv : the preprint server for health sciences · 2026Article
- Rates and Outcomes of Head and Neck Cancer Among Patients With Primary Immunodeficiency Disorders.Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · 2026Article
- Cancer Risk After Simultaneous Pancreas-Kidney Transplantation Compared With Kidney Transplant Alone: A Propensity-Matched Cohort Study.Clinical transplantation · 2026Article
- Beyond Immunosuppression: Defining Perioperative Risk in Transplant Patients Undergoing Colorectal and Small Bowel Surgery.World journal of surgery · 2026Article
- Review
- Impact of Hereditary Cancer Susceptibility in Solid-Organ Transplant Recipients.JCO precision oncology · 2026Article
- Mammographic Calcifications in Lung Transplant Recipients: Prevalence and Evolution.Biomedicines · 2025Article
- Immune Checkpoint Inhibitors in Kidney Transplant Recipients: A French Multicenter Retrospective Cohort Study.Transplantation direct · 2025Article
- Conditions Associated With the Onset of Cancer After Heart Transplant: Longitudinal Study in 335 Recipients.Clinical transplantation · 2025Observational
- Surgical outcomes of colorectal cancer surgery in transplant recipients: A matched case-control study.Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland · 2025Article
- Surgical Management of Renal Cell Carcinoma in Transplanted Kidneys-A Narrative Review.Cancers · 2025Review
- Cure models, survival probabilities, and solid organ transplantation for patients with colorectal cancer.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2025Article
- Outcomes in solid organ transplant recipients with a pretransplant diagnosis of melanoma.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2024Article
- Tumorigenic role of tacrolimus through mTORC1/C2 activation in post-transplant renal cell carcinomas.British journal of cancer · 2024Article
- Previous Solid Organ Transplantation Influences Both Cancer Treatment and Survival Among Colorectal Cancer Patients.Transplant international : official journal of the European Society for Organ Transplantation · 2024Article
- Post-Kidney Transplant Cancer: A Real-World Retrospective Analysis From a Single Italian Center.Transplant international : official journal of the European Society for Organ Transplantation · 2024Article
- Prior cancer history and suitability for kidney transplantation.Clinical kidney journal · 2023Review
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Authors and funding
9 authors at 7 institutions in 2 countries.
Funding
Abstract
backgroundTransplant recipients have an elevated risk of cancer because of immunosuppressive medications used to prevent organ rejection, but to the authors' knowledge no study to date has comprehensively examined associations between transplantation status and mortality after a cancer diagnosis.
methodsThe authors assessed cases in the US general population (N=7,147,476) for 16 different cancer types as ascertained from 11 cancer registries. The presence of a solid organ transplant prior to diagnosis (N=11,416 cancer cases) was identified through linkage with the national transplantation registry (1987-2014). Cox models were used to examine the association between transplantation status and cancer-specific mortality, adjusting for demographic characteristics and cancer stage.
resultsFor the majority of cancers, cancer-specific mortality was higher in transplant recipients compared with other patients with cancer. The increase was particularly pronounced for melanoma (adjusted hazard ratio [aHR], 2.59; 95% confidence interval [95% CI], 2.18-3.00) and cancers of the breast (aHR, 1.88; 95% CI, 1.61-2.19), bladder (aHR, 1.85; 95% CI, 1.58-2.17), and colorectum (aHR, 1.77; 95% CI, 1.60-1.96), but it also was increased for cancers of the oral cavity/pharynx, stomach, pancreas, kidney, and lung as well as diffuse large B-cell lymphoma (aHR range, 1.21-1.47). Associations remained significant after adjustment for first-course cancer treatment and generally were stronger among patients with local-stage cancers for whom potentially curative treatment was provided, including patients with melanoma (aHR, 3.82; 95% CI, 2.94-4.97) and cancers of the colorectum (aHR, 2.77; 95% CI, 2.07-3.70), breast (aHR, 2.08; 95% CI, 1.50-2.88), and prostate (aHR, 1.60; 95% CI, 1.12-2.29), despite the lack of an association for prostate cancer overall.
conclusionsFor multiple cancer types, transplant recipients with cancer appear to have an elevated risk of dying of their cancer, even after adjustment for stage and treatment, which may be due to impaired immunity.
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