ArticleInternational journal of epidemiology2019
Patterns of body mass index milestones in early life and cardiometabolic risk in early adolescence.
Article in International journal of epidemiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 1 of them a synthesis that pooled it.
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Who cites it
44 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Age at adiposity rebound and the relevance for obesity: a systematic review and meta-analysis.International journal of obesity (2005) · 2022Pooled it
- Association of cow's milk intake in early childhood with adiposity and cardiometabolic risk in early adolescence.The American journal of clinical nutrition · 2022Trial
- Cesarean delivery and overweight at 6 years of age: a prospective cohort analysis of the Japan Environment and Children's Study.European journal of pediatrics · 2026Article
- Prenatal Internal Exposure to Polycyclic Aromatic Hydrocarbons, Maternal Genetic Susceptibility, and Child Growth Trajectories: Evidence from a Prospective Cohort Study.Environmental science & technology · 2026Article
- Impact of growth markers and patterns of growth on children's cardiometabolic health: a life course perspective.World journal of pediatrics : WJP · 2026Article
- Caregiver Feeding Practices and Late-Preschool BMI-for-Age z-Score Trajectories Among WIC-Enrolled Children: A National Longitudinal Study.Nutrients · 2026Article
- Timing matters: a prospective investigation of father absence and pubertal timing in girls and boys.Biology of sex differences · 2026Article
- Predicting later ADHD presentation types from early childhood autism and intellectual disability.European child & adolescent psychiatry · 2025Article
- The Contribution of BMI to a Young Child's Risk of Islet Autoimmunity Is Dependent on HLA-DR4-DQ8 Without HLA-DR3-DQ2.Diabetes care · 2025Article
- Phthalates exposure and longitudinal trajectories of body composition and regional fat distribution in children: shifting towards "apple-shaped" body and the role of physical activity.BMC public health · 2025Article
- Differences in Physical Fitness According to Nutritional Status Among Rural Schoolchildren.Journal of functional morphology and kinesiology · 2025Article
- Classification of childhood obesity using longitudinal clinical body mass index and its validation.International journal of obesity (2005) · 2025Observational
- Timing based clustering of childhood BMI trajectories reveals differential maturational patterns; Study in the Northern Finland Birth Cohorts 1966 and 1986.International journal of obesity (2005) · 2025Article
- Early-Life Factors and Body Mass Index Trajectories Among Children in the ECHO Cohort.JAMA network open · 2025Article
- Article
- Cohort Profile Update: Project Viva Offspring.International journal of epidemiology · 2024Article
- Associations of prenatal exposure to bisphenols with BMI growth trajectories in offspring within the first two years: evidence from a birth cohort study in China.World journal of pediatrics : WJP · 2024Article
- Associations of childhood BMI traits with blood pressure and glycated haemoglobin in 6-9-year-old Samoan children.Pediatric obesity · 2024Article
- Timing of gestational diabetes diagnosis, gestational weight gains and offspring growth trajectory: a prospective birth cohort study.BMC pregnancy and childbirth · 2023Article
- Post hoc subgroup analysis and identification-learning more from existing data.European journal of clinical nutrition · 2023Article
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Authors and funding
9 authors.
Funding
Abstract
backgroundFew studies have examined the independent and combined relationships of body mass index (BMI) peak and rebound with adiposity, insulin resistance and metabolic risk later in life. We used data from Project Viva, a well-characterized birth cohort from Boston with repeated measures of BMI, to help fill this gap.
methodsAmong 1681 children with BMI data from birth to mid childhood, we fitted individual BMI trajectories using mixed-effects models with natural cubic splines and estimated age, and magnitude of BMI, at peak (in infancy) and rebound (in early childhood). We obtained cardiometabolic measures of the children in early adolescence (median 12.9 years) and analysed their associations with the BMI parameters.
resultsAfter adjusting for potential confounders, age and magnitude at infancy BMI peak were associated with greater adolescent adiposity, and earlier adiposity rebound was strongly associated with greater adiposity, insulin resistance and metabolic risk score independently of BMI peak. Children with a normal timing of BMI peak plus early rebound had an adverse cardiometabolic profile, characterized by higher fat mass index {β 2.2 kg/m2 [95% confidence interval (CI) 1.6, 2.9]}, trunk fat mass index [1.1 kg/m2 (0.8, 1.5)], insulin resistance [0.2 units (0.04, 0.4)] and metabolic risk score [0.4 units (0.2, 0.5)] compared with children with a normal BMI peak and a normal rebound pattern. Children without a BMI peak (no decline in BMI after the rise in infancy) also had adverse adolescent metabolic profiles.
conclusionsEarly age at BMI rebound is a strong risk factor for cardiometabolic risk, independent of BMI peak. Children with a normal peak-early rebound pattern, or without any BMI decline following infancy, are at greatest risk of adverse cardiometabolic profile in adolescence. Routine monitoring of BMI may help to identify children who are at greatest risk of developing an adverse cardiometabolic profile in later life and who may be targeted for preventive interventions.
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