Evidence map›Paper›PMID 30624677›Full record

ArticleThe Journal of nutrition2019

Diet Quality Is Low and Differs by Sex in People with HIV.

Julian J Weiss, Laura Sanchez, Jane Hubbard, Janet Lo, Steven K Grinspoon, Kathleen V Fitch

Registry-linked trialOpen access · bronzeAbstract read
In one paragraph

Article in The Journal of nutrition, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00455793 (Subclinical Atherosclerosis in HIV-infected Patients), which is not on this map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00455793 completednot on this map

Subclinical Atherosclerosis in HIV-infected Patients

TypeobservationalSponsorMassachusetts General HospitalRan2006 to 2013Enrolled263ConditionsHIV Infections, Coronary Atherosclerosis
3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.

  1. Pooled it
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  17. Diabetes in People with HIV.Current diabetes reports · 2021
    Review
  18. Review
  19. Review
  20. A Review of Chronic Comorbidities in Adults Living With HIV: State of the Science.The Journal of the Association of Nurses in AIDS Care : JANAC
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Julian J WeissProgram in Nutritional Metabolism, Massachusetts General Hospital and Harvard Medical School, Boston, MA.
Laura SanchezProgram in Nutritional Metabolism, Massachusetts General Hospital and Harvard Medical School, Boston, MA.
Jane HubbardTranslational and Clinical Research Center, Massachusetts General Hospital, Boston, MA.
Janet LoProgram in Nutritional Metabolism, Massachusetts General Hospital and Harvard Medical School, Boston, MA.
Steven K GrinspoonProgram in Nutritional Metabolism, Massachusetts General Hospital and Harvard Medical School, Boston, MA.
Kathleen V FitchProgram in Nutritional Metabolism, Massachusetts General Hospital and Harvard Medical School, Boston, MA.
Harvard University · USMassachusetts General Hospital · US

Funding

HARVARD CLINICAL AND TRANSLATIONAL SCIENCE CENTER (UL1)UL1RR025758 · NCRR · HARVARD MEDICAL SCHOOL · PI NADLER, LEE MARSHALL · 2008 to 2011
$91.4M
ZD6416 Analgesic--Painful Distal Symmetrical PolyneuropaM01RR001066 · NCRR · MASSACHUSETTS GENERAL HOSPITAL · PI HALL, JANET E · 1985 to 2008
$37.4M
ROLE OF DIETARY CONSTITUENTS ON GENE EXPRESSION IN INTESTINAL EPITHELIUMP30DK040561 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI Elizabeth Austen Lawson, Takara Leah Stanley · 1994 to 2026
$31.6M
Harvard Clinical and Translational Science Center (UL1)UL1TR000170 · NCATS · HARVARD MEDICAL SCHOOL · PI NADLER, LEE MARSHALL · 2012 to 2013
$31.4M
Atherosclerosis and Inflammation in HIV DiseaseK23HL092792 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI LO, JANET · 2008 to 2012
$705k
Subclinical Coronary Atherosclerosis in HIV-Infected PatientsF32HL088991 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI LO, JANET · 2007 to 2007
$12k
NCATS NIH HHS UL1 TR000170NCRR NIH HHS M01 RR001066NCRR NIH HHS UL1 RR025758NHLBI NIH HHS F32 HL088991NHLBI NIH HHS K23 HL092792NIDDK NIH HHS P30 DK040561
6 · The paper itself

Abstract

Background: People with HIV (PWH) are at risk for developing metabolic comorbidities driven, in part, by immune activation/inflammation. Little is known about diet quality, a potential modifiable factor in PWH. Objectives: This study aimed to explore diet quality in terms of conformance with US dietary guidelines by calculating Healthy Eating Index-2010 (HEI) scores among adults with and without HIV in Boston, MA, and determine associations with HEI and markers of immune activation/inflammation. Methods: One-hundred and three HIV-infected [50 women, 53 men; mean ± SD age: 47 ± 7 y; body mass index (BMI, in kg/m2): 26 ± 5] and 38 uninfected adults (17 women, 21 men; age: 46 ± 7 y; BMI: 28 ± 4) were included in this cross-sectional analysis. Participants who completed a 4-d food record from which HEI could be calculated were included. HEI was compared between participants with and without HIV, within HIV-infected participants stratified by sex, and by HIV serostatus and sex. In the HIV group, predictors of HEI were determined in multivariable modeling. Univariate associations with diet quality and inflammation/immune markers were assessed. Results: The HEI score was 51.3 in the HIV-infected participants and 57.3 in the HIV-uninfected participants (P = 0.052). In the comparison by HIV serostatus and sex, HIV-infected women had significantly lower HEI (49.2) compared with HIV-infected men (55.7) (P = 0.005) and HIV-uninfected men (61.8) (P = 0.002). Adjusting for potential confounding factors, sex remained an independent predictor of HEI in HIV (P = 0.02). In the HIV group, higher log HEI was associated with lower concentration of the immune activation marker sCD14 (P = 0.009). Conclusions: Diet quality tended to be lower in HIV-infected individuals compared with HIV-uninfected individuals and was lower among HIV-infected women compared with HIV-infected men, and HIV-uninfected men. There may also be an association with diet quality and sCD14 in PWH. Future prospective studies are needed to confirm these findings and determine whether improving diet quality is a useful strategy to reduce metabolic abnormalities in this population. This study was registered at clinicaltrials.gov as NCT00455793.

Indexed as

HIV InfectionsAdultBostonCross-Sectional StudiesDietDiet, HealthyDiet SurveysFemaleHumansMaleMiddle AgedNutrition PolicyProspective StudiesSex Factors

Identifiers

PMID30624677
PMCPMC6351143
OpenAlexW2911096807

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.