ReviewMemorias do Instituto Oswaldo Cruz2019
Origin, tempo, and mode of the spread of DENV-4 Genotype IIB across the state of São Paulo, Brazil during the 2012-2013 outbreak.
Review in Memorias do Instituto Oswaldo Cruz, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Acute Febrile Illness Associated with an Emerging Dengue 4 GIIb Variant Causing Epidemic in León, Nicaragua 2022.Viruses · 2025Article
- Article
- Global and local evolutionary dynamics of Dengue virus serotypes 1, 3, and 4.Epidemiology and infection · 2023Article
- Article
- Systemic dengue infection associated with a new dengue virus type 2 introduction in Brazil - a case report.BMC infectious diseases · 2021Article
- Article
- Geoclimatic, demographic and socioeconomic characteristics related to dengue outbreaks in Southeastern Brazil: an annual spatial and spatiotemporal risk model over a 12-year period.Revista do Instituto de Medicina Tropical de Sao Paulo · 2021Article
- Genomic Epidemiology as a Public Health Tool to Combat Mosquito-Borne Virus Outbreaks.The Journal of infectious diseases · 2020Review
- Genomic detection of a virus lineage replacement event of dengue virus serotype 2 in Brazil, 2019.Memorias do Instituto Oswaldo Cruz · 2020Article
- Origin of the São Paulo Yellow Fever epidemic of 2017-2018 revealed through molecular epidemiological analysis of fatal cases.Scientific reports · 2019Article
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7 authors.
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Abstract
backgroundDengue virus type 4 (DENV-4) was first reported in Brazil in 1982 and since then no more cases were detected again in Brazil until 2010, when the virus was reintroduced. Over the following years, the virus spread to several Brazilian states and resulted in about 1,400,000 dengue cases, in 2013. The largest number of cases were documented in the Southeast macro-region.
objectivesTo determine the phylogeography of DENV-4 Genotype IIB strains isolated during the epidemics in 2012-2013 in São Paulo, Brazil, we aimed to contextualise the contribution of viruses sampled in different localities across the overall movement of DENV-4 in Brazil.
methodsBased on the envelope gene sequences retrieved from GenBank, we employed a Bayesian phylogeographic approach to assess the spatiotemporal dynamics of DENV-4 Genotype IIB in São Paulo, Brazil.
findingsThe dispersal dynamics of DENV-4 Genotype IIB in Brazil indicated Rio de Janeiro and Mato Grosso states as the most likely routes toward São Paulo before the 2012-2013 outbreak. Likewise, Guarujá and São José do Rio Preto facilitated viral spread and transmission to other localities in the South and Southeast macro-regions in Brazil.
conclusionsThe spread pattern of DENV-4 Genotype IIB strains across the country supports two independent introductions of the virus in São Paulo in a short period of time. Furthermore, São Paulo appears to have played a pivotal role in the dissemination of DENV-4 to other locations in Brazil.
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