Evidence map›Paper›PMID 30624087›Full record

ReviewClimacteric : the journal of the International Menopause Society2019

The etiology and management of recurrent urinary tract infections in postmenopausal women.

Carrie Jung, Linda Brubaker

Registry-linked trialOpen access · greenAbstract readReview
In one paragraph

Review in Climacteric : the journal of the International Menopause Society, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05318365 (Bladder and Bowel Dysfunction in Children), which is not on this map. Cited by 67 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
67citing papers in PubMed, 2 pooled it
9.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05318365 naunknown statusnot on this mapstarted 2022, after this paper: background citation

Bladder and Bowel Dysfunction in Children

TypeinterventionalSponsorUniversity of AarhusRan2022 to 2025Enrolled100ConditionsBladder and Bowel DysfunctionArmsPolyethylene Glycol 3350, Urotherapy
3 · Its place in the literature

Who cites it

67 citing papers in PubMed, 2 syntheses or guidelines pooled it, 156 citations in OpenAlex.

  1. Descriptive Epidemiology ofBioMed research international · 2025
    Pooled it
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  7. Article
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  9. Sexual Wellbeing and Urinary Tract Infections: A Scoping Review.International urogynecology journal · 2026
    Review
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7 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Carrie Junga Department of Obstetrics, Gynecology and Reproductive Sciences, Division of Female Pelvic Medicine and Reconstructive Surgery , University of California San Diego , La Jolla , CA , USA.
Linda Brubakera Department of Obstetrics, Gynecology and Reproductive Sciences, Division of Female Pelvic Medicine and Reconstructive Surgery , University of California San Diego , La Jolla , CA , USA.ORCID 0000-0002-8598-2589
University of California San Diego · US

Funding

The Female Urinary Microbiome and Urinary IncontinenceR01DK104718 · NIDDK · LOYOLA UNIVERSITY CHICAGO · PI BRUBAKER, LINDA, WOLFE, ALAN J · 2016 to 2020
$3.1M
NIDDK NIH HHS R01 DK104718
6 · The paper itself

Abstract

Urinary tract infections (UTIs) are one of the most common infections and affect up to 50% of women in their lifetime, with almost half of these women experiencing a recurrence in 6-12 months. Menopause predisposes women to recurrent UTI (rUTI), as normally lower levels of estrogen lead to changes in the urogenital epithelium and subsequently urogenital microbiome. The recently discovered urobiome is now known to have different compositions in both healthy and unhealthy bladders, including a role in the pathophysiology of rUTI, and may be a therapeutic target for prevention and treatment options for rUTI. In postmenopausal women with frequent UTI, the diagnosis of acute UTI should be made using a combination of the symptom assessment and urine diagnostic studies. The choice of UTI antibiotic should include consideration of efficacy, collateral effects, and side-effects. Some women may be candidates for self-start therapy, in which the patient accurately recognizes her UTI symptoms and then starts previously prescribed antibiotics. A large component of the management of women with rUTI is prevention. Urobiome research for bladder health and disease is a young field of investigation with significant potential to improve care for postmenopausal women affected by rUTI through novel, evidence-based prevention and treatment strategies.

Indexed as

PostmenopauseAgedAged, 80 and overAnti-Bacterial AgentsEpitheliumEstrogen Replacement TherapyEstrogensFemaleHumansMicrobiotaMiddle AgedRecurrenceRisk FactorsUrinary Tract InfectionsUrogenital SystemAnti-Bacterial AgentsEstrogensbladderbladder healthUrinary microbiomeurinary tract infectionurobiome

Identifiers

PMID30624087
PMCPMC6629580
OpenAlexW2910045600

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.