Evidence map›Paper›PMID 30623723›Full record

ArticleAmerican journal of physiology. Renal physiology2019

Identification of NFAT5 as a transcriptional regulator of the EDN1 gene in collecting duct.

Jayalakshmi Lakshmipathi, Will Wheatley, Anil Kumar, Gaelle Mercenne, Aylin R Rodan, Donald E Kohan

Open access · bronzeAbstract read
In one paragraph

Article in American journal of physiology. Renal physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.3field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Acclimation to a High-Salt Diet Is Sex Dependent.Journal of the American Heart Association · 2022
    Article
  5. NFAT5, which protects against hypertonicity, is activated by that stress via structuring of its intrinsically disordered domain.Proceedings of the National Academy of Sciences of the United States of America · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Jayalakshmi LakshmipathiDivision of Nephrology, University of Utah Health Sciences Center , Salt Lake City, Utah.
Will WheatleyDivision of Nephrology, University of Utah Health Sciences Center , Salt Lake City, Utah.
Anil KumarMetabolic Phenotyping Core, University of Utah Health Sciences Center , Salt Lake City, Utah.
Gaelle MercenneDivision of Nephrology, University of Utah Health Sciences Center , Salt Lake City, Utah.
Aylin R RodanDivision of Nephrology, University of Utah Health Sciences Center , Salt Lake City, Utah.
Donald E KohanDivision of Nephrology, University of Utah Health Sciences Center , Salt Lake City, Utah.
University of Utah · US

Funding

Research Supplement to Promote DiversityP01HL136267 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI POLLOCK, DAVID M · 2017 to 2021
$11.9M
Renal endothelin receptor-specific function in angiotensin ll-dependent hypertensP01HL095499 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI SULLIVAN, JENNIFER C · 2010 to 2014
$11.1M
Regulation of WNK signaling by potassium and Mo25: structure, function and physiologyR01DK110358 · NIDDK · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI RODAN, AYLIN RACHEL · 2016 to 2025
$4.1M
NHLBI NIH HHS P01 HL095499NHLBI NIH HHS P01 HL136267NIDDK NIH HHS R01 DK110358
6 · The paper itself

Abstract

The inner medullary collecting duct (IMCD) produces very high levels of endothelin-1 (ET-1) that acts as an autocrine inhibitor of IMCD Na

Indexed as

Gene Expression RegulationAnimalsCell LineClustered Regularly Interspaced Short Palindromic RepeatsEndothelin-1Kidney Tubules, CollectingMiceNFATC Transcription FactorsPromoter Regions, GeneticRNA, Small InterferingEndothelin-1NFATC Transcription FactorsRNA, Small Interferingendothelin-1inner medullary collecting ductNFAT5osmolaritypromoter

Identifiers

PMID30623723
PMCPMC6442376
OpenAlexW2910443485

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.