ArticleMolecular and cellular biology1988
A short-lived nuclear phosphoprotein encoded by the human ets-2 proto-oncogene is stabilized by activation of protein kinase C.
Article in Molecular and cellular biology, 1988. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 61 citations in OpenAlex.
- USP39-Mediated Non-Proteolytic Control of ETS2 Suppresses Nuclear Localization and Activity.Biomolecules · 2023Article
- Identification of pathological transcription in autosomal dominant polycystic kidney disease epithelia.Scientific reports · 2021Article
- Mutant p53 cooperates with ETS2 to promote etoposide resistance.Genes & development · 2012Article
- Role for Ets-2(Thr-72) transcription factor in stage-specific thymocyte development and survival.The Journal of biological chemistry · 2012Article
- Ets2-dependent stromal regulation of mouse mammary tumors.Molecular and cellular biology · 2003Article
- Ets2 and protein kinase C epsilon are important regulators of parathyroid hormone-related protein expression in MCF-7 breast cancer cells.The Biochemical journal · 2003Article
- Review
- Defective trophoblast function in mice with a targeted mutation of Ets2.Genes & development · 1998Article
- Constitutive expression of c-fos and c-jun, overexpression of ets-2, and reduced expression of metastasis suppressor gene nm23-H1 in rheumatoid arthritis.Annals of the rheumatic diseases · 1996Article
- ERF: an ETS domain protein with strong transcriptional repressor activity, can suppress ets-associated tumorigenesis and is regulated by phosphorylation during cell cycle and mitogenic stimulation.The EMBO journal · 1995Article
- ets-1 in astrocytes: expression and transmitter-evoked phosphorylation.Molecular and cellular biology · 1995Article
- Participation of Ets transcription factors in the glucocorticoid response of the rat tyrosine aminotransferase gene.Molecular and cellular biology · 1994Article
- DNA-binding and transcriptional activation properties of the EWS-FLI-1 fusion protein resulting from the t(11;22) translocation in Ewing sarcoma.Molecular and cellular biology · 1994Article
- Ets transcription factor binding site is required for positive and TNF alpha-induced negative promoter regulation.Nucleic acids research · 1993Article
- Synergistic activation of the HTLV1 LTR Ets-responsive region by transcription factors Ets1 and Sp1.The EMBO journal · 1993Article
- A positive regulator of the ribosomal protein gene, beta factor, belongs to the ETS oncoprotein family.The Biochemical journal · 1992Article
- A novel Ets-related transcription factor, Elf-1, binds to human immunodeficiency virus type 2 regulatory elements that are required for inducible trans activation in T cells.Journal of virology · 1992Article
- Simultaneous expression of T-cell and myeloid cell phenotypes in eight newly established HTLV-I-positive T-cell lines.Japanese journal of cancer research : Gann · 1992Article
- Role of the PU.1 transcription factor in controlling differentiation of Friend erythroleukemia cells.Molecular and cellular biology · 1992Article
- Expression of a 91-kilodalton PEA3-binding protein is down-regulated during differentiation of F9 embryonal carcinoma cells.Molecular and cellular biology · 1992Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The human ets-2 gene is a homolog of the v-ets oncogene of the E26 virus and codes for a 56-kilodalton nuclear protein. The ets-2 protein is phosphorylated and has a rapid turnover, with a half-life of 20 min. When human lymphocytic CEM cells were treated with the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA), the level of the ets-2 protein was quickly elevated 5- to 20-fold. This effect of TPA was mimicked by a synthetic diacylglycerol, 1-oleoyl-2-acetyl glycerol, and was blocked by the protein kinase C inhibitor H7, indicating that protein kinase C is involved in the induction. The increase in the ets-2 protein was due to stabilization of the protein, because the protein had a half-life of more than 2 h in the presence of TPA and the ets-2 mRNA level did not increase significantly upon TPA treatment. The protein synthesis inhibitor cycloheximide enhanced the effect of TPA on the ets-2 protein and could itself slow turnover of the protein. Properties of the ets-2 protein, such as nuclear localization, phosphorylation, rapid turnover, and response to protein kinase C, indicate that this protein belongs to a group of oncogene proteins which are generally thought to have regulatory functions in the nucleus (e.g., myc, fos, myb, and p53). Our results suggest that protein kinase C, either directly or indirectly, regulates the level of the ets-2 protein by posttranslational mechanisms.
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