ArticleMolecular and cellular biology1988
ROX1 encodes a heme-induced repression factor regulating ANB1 and CYC7 of Saccharomyces cerevisiae.
Article in Molecular and cellular biology, 1988. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
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50 citing papers in PubMed, 115 citations in OpenAlex.
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- Oxygen-responsive transcriptional regulation of lipid homeostasis in fungi: Implications for anti-fungal drug development.Seminars in cell & developmental biology · 2018Review
- Decoupling of divergent gene regulation by sequence-specific DNA binding factors.Nucleic acids research · 2015Article
- Repression of the Low Affinity Iron Transporter Gene FET4: A NOVEL MECHANISM AGAINST CADMIUM TOXICITY ORCHESTRATED BY YAP1 VIA ROX1.The Journal of biological chemistry · 2015Article
- Transcriptional regulation of yeast oxidative phosphorylation hypoxic genes by oxidative stress.Antioxidants & redox signaling · 2013Article
- The nuclear localization of SWI/SNF proteins is subjected to oxygen regulation.Cell & bioscience · 2012Article
- Hypoxia elicits broad and systematic changes in protein subcellular localization.American journal of physiology. Cell physiology · 2011Article
- Deletion of a subgroup of ribosome-related genes minimizes hypoxia-induced changes and confers hypoxia tolerance.Physiological genomics · 2011Article
- Biosynthetic and iron metabolism is regulated by thiol proteome changes dependent on glutaredoxin-2 and mitochondrial peroxiredoxin-1 in Saccharomyces cerevisiae.The Journal of biological chemistry · 2011Article
- Regulation of hypoxia adaptation: an overlooked virulence attribute of pathogenic fungi?Medical mycology · 2010Review
- A predictive model of the oxygen and heme regulatory network in yeast.PLoS computational biology · 2008Article
- Combinatorial influence of environmental parameters on transcription factor activity.Bioinformatics (Oxford, England) · 2008Article
- Heme levels switch the function of Hap1 of Saccharomyces cerevisiae between transcriptional activator and transcriptional repressor.Molecular and cellular biology · 2007Article
- Synergy among differentially regulated repressors of the ribonucleotide diphosphate reductase genes of Saccharomyces cerevisiae.Eukaryotic cell · 2006Article
- Genetic factors that regulate the attenuation of the general stress response of yeast.Genetics · 2005Article
- The heme activator protein Hap1 represses transcription by a heme-independent mechanism in Saccharomyces cerevisiae.Genetics · 2005Article
- Role of Candida albicans transcription factor Upc2p in drug resistance and sterol metabolism.Eukaryotic cell · 2004Article
- Recruitment of Tup1-Ssn6 by yeast hypoxic genes and chromatin-independent exclusion of TATA binding protein.Eukaryotic cell · 2003Article
- Synergistic repression of anaerobic genes by Mot3 and Rox1 in Saccharomyces cerevisiae.Nucleic acids research · 2003Article
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The ROX1 gene encodes a product implicated in the regulation of heme-repressed and heme-induced genes in Saccharomyces cerevisiae. The gene has been cloned and shown to code for a 1.4-kilobase transcript. The cloned gene was used to construct a null mutant to determine the role of ROX1 in regulating the expression of several heme-regulated genes. Constitutive expression of ANB1 (a heme-repressed gene) was observed in the null strain, indicating that ROX1 codes for a repressor or a facilitator of repression. Enhancement of expression of CYC7 in the null strain indicated that the ROX1 factor is required for repression of CYC7 to its normal low level of expression, consistent with evidence that CYC7 has a hybrid heme-induced, heme-repressed regulatory mechanism. The null mutation had only a slight negative effect on expression of the heme-induced genes CYC1 and tr-1 (a heme-induced homolog of ANB1), suggesting that the ROX1 factor is not directly involved in their regulation despite the existence of an unusual rox1 mutation (rox1-a1) causing constitutive expression of this group. The respiratory competence of the null mutant indicates that ROX1 is not a respiratory factor. ROX1 expression was found to be induced by heme, indicating that the heme repression of ANB1 and its family is the result of a cascade in which heme induces a repression factor which keeps the family of heme-repressed genes inactive during aerobic growth. The rox1-a1 allele had earlier been shown to cause constitutive expression of the family of heme-induced respiratory genes. This allele was found to cause constitutive expression of the ROX1 transcript itself, indicating that ROX1 is in the major heme-induced regulon.
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