ArticleAnnals of laboratory medicine2019
Small Red Blood Cell Fraction on the UF-1000i Urine Analyzer as a Screening Tool to Detect Dysmorphic Red Blood Cells for Diagnosing Glomerulonephritis.
Article in Annals of laboratory medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 16 citations in OpenAlex.
- Enhancing Glomerular Hematuria Identification in Automated Urinalysis Using a Light Gradient Boosting Machine-Based Model: A Diagnostic Accuracy Study.Annals of laboratory medicine · 2026Article
- Urinary Red Blood Cell Distribution for Detection of Glomerular Hematuria: A Biopsy-Based Comparison with Direct Microscopy.Diagnostics (Basel, Switzerland) · 2026Article
- Machine Learning-Based Analysis of UF-5000 Scattergrams Improves the Identification of Urinary Dysmorphic Red Blood Cells.Annals of laboratory medicine · 2026Article
- Development of a Novel UPC (Urine Red Blood Cell Distribution, Proteinuria, and Serum Creatinine) Index to Differentiate Glomerular from Nonglomerular Hematuria.Journal of clinical laboratory analysis · 2026Article
- Comparative evaluation of three automated urine sediment analyzers excluding cutoff-related trade-offs.iScience · 2026Article
- Performance verification of the new UF-1500 urine particle analyser: a new opportunity for small and medium laboratories.Practical laboratory medicine · 2025Article
- Comparison of Urinary Red Blood Cell Distribution (URD) and Dysmorphic Red Blood Cells for Detecting Glomerular Hematuria: A Multicenter Study.Journal of clinical laboratory analysis · 2025Article
- Diagnostic Characteristics of Urinary Red Blood Cell Distribution Incorporated in UF-5000 for Differentiation of Glomerular and Non-Glomerular Hematuria.Annals of laboratory medicine · 2022Article
- Internal Quality Control Data of Urine Reagent Strip Tests and Derivation of Control Rules Based on Sigma Metrics.Annals of laboratory medicine · 2021Article
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Authors and funding
6 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundDysmorphic red blood cells (dRBCs) are first-line biomarkers for detecting glomerulonephritis (GN) in patients with hematuria. The UF-1000i system (Sysmex, Kobe, Japan), based on flow cytometry, provides small red blood cell (RBC) values (UF-1000i [UF]-%sRBCs). We evaluated the clinical application of UF-%sRBCs for detecting %dRBCs and GN.
methodsUrine samples of 103 patients (47 with GN; 56 without GN [NGN]) were analyzed using UF-1000i urinalysis, phase-contrast microscopy (PCM), and urine chemistry. Serum creatinine (mg/dL), serum albumin (g/dL), serum protein (mg/dL), urine protein (mg/dL), and urea nitrogen (mg/dL) levels were measured using an automated chemical analyzer. To determine the cut-off level of predicting GN, ROC curve was analyzed.
resultsUF-%sRBCs, %dRBCs, urine protein, serum creatinine, and estimated-glomerular filtration rate differed between the GN and NGN groups, with the greatest differences detected for UF-%sRBCs and %dRBCs (
conclusionsUF-%sRBCs had similar diagnostic power to %dRBCs determined by PCM for identifying patients with GN. UF-%sRBCs may be more useful for diagnosing GN in patients with isolated hematuria. Predicting %dRBCs using UF-1000i will provide information on possible GN in patients presenting with asymptomatic hematuria.
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