Evidence map›Paper›PMID 30623603›Full record

ArticleMolecular genetics & genomic medicine2019

Impact of IL1R1 and IL1R2 gene polymorphisms on risk of osteonecrosis of the femoral head from a case-control study.

Feimeng An, Jiaqi Wang, Hongyan Gao, Chang Liu, Ye Tian, Tianbo Jin, Wanlin Liu, Jianzhong Wang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular genetics & genomic medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.6field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
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  4. Relationship BetweenPharmacogenomics and personalized medicine · 2021
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  6. The association of genetic polymorphisms in interleukin-1 receptors type 1 and type 2 with age-related hearing impairment in a Taiwanese population: a case control study.Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale · 2020
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Feimeng AnInner Mongolia Medical University, Hohhot, Inner Mongolia, China.
Jiaqi WangInner Mongolia Medical University, Hohhot, Inner Mongolia, China.
Hongyan GaoDepartment of Trauma Orthopedics, the Second Affiliated Hospital of Inner Mongolia Medical University, Hohhot, Inner Mongolia, China.
Chang LiuInner Mongolia Medical University, Hohhot, Inner Mongolia, China.
Ye TianInner Mongolia Medical University, Hohhot, Inner Mongolia, China.
Tianbo JinKey Laboratory of Resource Biology and Biotechnology in Western China (Northwest University), Ministry of Education, School of Life Sciences, Northwest University, Xi'an, Shaanxi, China.ORCID 0000-0001-8378-6624
Wanlin LiuDepartment of Trauma Orthopedics, the Second Affiliated Hospital of Inner Mongolia Medical University, Hohhot, Inner Mongolia, China.
Jianzhong WangDepartment of Trauma Orthopedics, the Second Affiliated Hospital of Inner Mongolia Medical University, Hohhot, Inner Mongolia, China.ORCID 0000-0002-3633-5991
Second Affiliated Hospital of Inner Mongolia Medical University · CNMinistry of Education of the People's Republic of China · CNNorthwest University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimOsteonecrosis of the femoral head (ONFH) refers to bony changes caused by osteocyte death under the effects of complicated factors, which is caused by genetic factors and certain risk factors. Our study aimed to explore whether IL1R1/IL1R2 polymorphisms influenced ONFH risk in the Chinese Han population.

methodsWe selected 286 patients and 441 controls, with 11 single-nucleotide polymorphisms in IL1R1 and IL1R2 gene were successfully genotyped, and evaluated the associations using the chi-squared test, Fisher's exact test, T test, and genetic model analyses. Odds ratios and 95% confidence intervals (CIs) were calculated using unconditional logistic regression.

resultsIn the allele model, rs11674595 in IL1R2 was associated with increasing the risk of ONFH, the rs10490571 and rs3917225 in IL1R1 gene were associated with an increased risk of ONFH, respectively. In the genetic model, the rs11674595 in IL1R2 gene was associated with an increased risk of ONFH in the codominant model, dominant model, and log-additive model, respectively. The rs10490571 and rs3917225 in IL1R1 gene conferred an increased risk of ONFH in the codominant model, dominant model, and log-additive model, respectively. We found none of the haplotypes in the IL1R2 gene was significantly associated with theONFH risk.

conclusionOur findings have demonstrated that the rs11674595 (IL1R2), rs10490571, and rs3917225 (IL1R1) were significantly associated with increasing the ONFH risk in the Chinese Han population.

Indexed as

Polymorphism, Single NucleotideAdultChinaFemaleFemur Head NecrosisHumansMaleMiddle AgedReceptors, Interleukin-1 Type IReceptors, Interleukin-1 Type IIIL1R1 protein, humanIL1R2 protein, humanReceptors, Interleukin-1 Type IReceptors, Interleukin-1 Type IIcase-control studyChinese Han populationgenetic polymorphismIL1R1IL1R2ONFH

Identifiers

PMID30623603
PMCPMC6418375
OpenAlexW2909950596

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.