ArticlePlant biotechnology journal2019
Metabolic engineering of bread wheat improves grain iron concentration and bioavailability.
Article in Plant biotechnology journal, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 102 citations in OpenAlex.
- Analysis of the TaNAS gene family in bread wheat identifies additional members and candidates for intragenic biofortification.Journal of experimental botany · 2026Article
- Machine learning-guided multi-omics suggests iron-dependent hormonal signaling drives root morphological plasticity in wheat under temperature stress.The New phytologist · 2026Article
- Effect of Germination on the Nutrient Profile, Antioxidant Components, Antinutritional Constituents, and Functional Characteristics of Barnyard Millet (Food science & nutrition · 2026Article
- From convention to innovation: the role of genetic modification and genome editing in Australian wheat breeding.AoB PLANTS · 2025Review
- Engineering of nicotianamine synthesis enhances cadmium mobility in plants and results in higher seed cadmium concentrations.The Plant journal : for cell and molecular biology · 2025Article
- Micronutrient Biofortification in Wheat: QTLs, Candidate Genes and Molecular Mechanism.International journal of molecular sciences · 2025Review
- Iron Content of Wheat and Rice in Australia: A Scoping Review.Foods (Basel, Switzerland) · 2024Article
- Nicotianamine: A Key Player in Metal Homeostasis and Hyperaccumulation in Plants.International journal of molecular sciences · 2023Review
- A two-gene strategy increases iron and zinc concentrations in wheat flour, improving mineral bioaccessibility.Plant physiology · 2023Article
- Biofortification to avoid malnutrition in humans in a changing climate: Enhancing micronutrient bioavailability in seed, tuber, and storage roots.Frontiers in plant science · 2023Review
- Critical assessment of wheat biofortification for iron and zinc: a comprehensive review of conceptualization, trends, approaches, bioavailability, health impact, and policy framework.Frontiers in nutrition · 2023Review
- Iron accumulation and partitioning in hydroponically grown wild and cultivated chickpea (Frontiers in plant science · 2023Article
- Overexpression ofPlants (Basel, Switzerland) · 2022Article
- Pleiotropic effect analysis and marker development for grain zinc and iron concentrations in spring wheat.Molecular breeding : new strategies in plant improvement · 2022Article
- Applications of Genomic Tools in Plant Breeding: Crop Biofortification.International journal of molecular sciences · 2022Review
- A Model to Incorporate the bHLH Transcription Factor OsIRO3 within the Rice Iron Homeostasis Regulatory Network.International journal of molecular sciences · 2022Article
- Genomic approaches for improving grain zinc and iron content in wheat.Frontiers in genetics · 2022Review
- Modification of storage proteins in the barley grain increases endosperm zinc and iron under both normal and elevated atmospheric COPhysiologia plantarum · 2022Article
- Cytokinin and Its Key Role to Enrich the Plant Nutrients and Growth Under Adverse Conditions-An Update.Frontiers in genetics · 2022Review
- Wheat Biofortification: Utilizing Natural Genetic Diversity, Genome-Wide Association Mapping, Genomic Selection, and Genome Editing Technologies.Frontiers in nutrition · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bread wheat (Triticum aestivum L.) is cultivated on more land than any other crop and produces a fifth of the calories consumed by humans. Wheat endosperm is rich in starch yet contains low concentrations of dietary iron (Fe) and zinc (Zn). Biofortification is a micronutrient intervention aimed at increasing the density and bioavailability of essential vitamins and minerals in staple crops; Fe biofortification of wheat has proved challenging. In this study we employed constitutive expression (CE) of the rice (Oryza sativa L.) nicotianamine synthase 2 (OsNAS2) gene in bread wheat to up-regulate biosynthesis of two low molecular weight metal chelators - nicotianamine (NA) and 2'-deoxymugineic acid (DMA) - that play key roles in metal transport and nutrition. The CE-OsNAS2 plants accumulated higher concentrations of grain Fe, Zn, NA and DMA and synchrotron X-ray fluorescence microscopy (XFM) revealed enhanced localization of Fe and Zn in endosperm and crease tissues, respectively. Iron bioavailability was increased in white flour milled from field-grown CE-OsNAS2 grain and positively correlated with NA and DMA concentrations.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.