Trial reportClinical oral investigations2019
Is the dentifrice containing calcium silicate, sodium phosphate, and fluoride able to protect enamel against chemical mechanical wear? An in situ/ex vivo study.
Trial report in Clinical oral investigations, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 23 citations in OpenAlex.
- The role of calcium in the prevention of erosive tooth wear: a systematic review and meta-analysis.Evidence-based dentistry · 2024Pooled it
- Pooled it
- Innovative dentifrices based on bioactive silica for enamel remineralization and erosion control: an in vitro study.BMC oral health · 2025Article
- Effect of the calcium silicate and sodium phosphate remineralizing products on bleached enamel.Journal of conservative dentistry and endodontics · 2024Article
- Combined use of stannous fluoride-containing mouth rinse and toothpaste prevents enamel erosion in vitro.Clinical oral investigations · 2023Article
- Topical Agents for Nonrestorative Management of Dental Erosion: A Narrative Review.Healthcare (Basel, Switzerland) · 2022Review
- Enamel erosion control by strontium-containing TiOClinical oral investigations · 2022Article
- Advanced non-fluoride approaches to dental enamel remineralization: The next level in enamel repair management.Biomaterials and biosystems · 2021Review
- Effectiveness of a toothpaste and a serum containing calcium silicate on protecting the enamel after interproximal reduction against demineralization.Scientific reports · 2021Article
- Protection of calcium silicate/sodium phosphate/fluoride toothpaste with serum on enamel and dentin erosive wear.Journal of applied oral science : revista FOB · 2021Article
- Stannous Fluoride Effects on Enamel: A Systematic Review.Biomimetics (Basel, Switzerland) · 2020Review
- Whitening Dentifrices Effect on Enamel with Orthodontic Braces after Simulated Brushing.European journal of dentistry · 2020Article
- Fluorotic Enamel Susceptibility to Dental Erosion and Fluoride Treatment.Brazilian dental journalArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
objectivesThe aim of this study was to investigate the effect of a dentifrice that contains calcium silicate, sodium phosphate, and fluoride on erosive-abrasive enamel wear. MATERIAL AND
methodsThis randomized, single-blind in situ/ex vivo study was conducted with four crossover phases of 5 days (one group tested per phase). Bovine enamel blocks (n = 256) were allocated to 16 volunteers and 8 groups. The groups under study were test dentifrice, with calcium silicate, sodium phosphate, and 1450 ppm sodium monofluorophosphate; tin dentifrice, with 3500 ppm stannous chloride, 700 ppm amine fluoride, and 700 ppm sodium fluoride; conventional dentifrice, with 1450 ppm sodium monofluorophosphate; and control (deionized water). Half of the enamel blocks were subjected to erosion and the other half to erosion plus abrasion. The daily extraoral protocol consisted in four citric acid exposures (2 min) and two applications of dentifrice slurry on all blocks for 30 s; after, half of the blocks were brushed for 15 s. The response variable was enamel loss. Data were analyzed by two-way ANOVA and Fisher's test (p < 0.05).
resultsFor erosion, the test dentifrice promoted less enamel loss than water (4.7 ± 3.1 and 5.8 ± 2.5 μm, respectively, p < 0.05), and did not differ from tin (4.8 ± 2.5 μm) and conventional (4.8 ± 1.4 μm) dentifrices (p > 0.05). However, the test dentifrice (7.7 ± 3.8 μm) promoted higher wear after erosive plus abrasive procedures than tin (5.4 ± 1.5 μm) and conventional (6.2 ± 1.7 μm, p < 0.05) dentifrices, and did not differ from water (6.9 ± 2.0 μm).
conclusionsThe investigated dentifrice reduced enamel loss against acid challenge but had no effect against acid and brushing challenge. CLINICAL RELEVANCE: Little is known regarding the preventive effect of dentifrices indicated for dental erosion. The tested anti-erosive dentifrice was unable to protect enamel when erosion was associated to toothbrushing abrasion.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.