Evidence map›Paper›PMID 30623305›Full record

ArticleHead and neck pathology2020

Recurrent Sinonasal CD34-Negative Malignant Solitary Fibrous Tumor Diagnosed on STAT6 Immunohistochemistry and NAB2-STAT6 Fusion.

Aanchal Kakkar, Pirabu Sakthivel, Madhu Rajeshwari, Arvind Kairo, Mehar C Sharma

Open access · bronzeAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Head and neck pathology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 2 pooled it
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 22 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Solitary fibrous tumor: an updated review.Journal of pathology and translational medicine · 2026
    Article
  4. Review
  5. Review
  6. Solitary Fibrous Tumor of Nasal Cavity: A Case Report.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2024
    Article
  7. [Transoral robotic surgery in the management of solitary fibrous tumor at the entrance of the hypolaryngeal esophagus: a case report and literature review].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2024
    Review
  8. Solitary fibrous tumor of the tongue.Autopsy & case reports · 2022
    Article
  9. Article
  10. Article
  11. Sinonasal IgG4-related disease: a rare and emerging entity broadening the differential diagnosis in the sinonasal universe.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2021
    Article
  12. Article
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Aanchal KakkarDepartment of Pathology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, 110029, India. aanchalkakkar@gmail.com.ORCID http://orcid.org/0000-0002-4303-1099
Pirabu SakthivelDepartment of Otolaryngology and Head and Neck Surgery, All India Institute of Medical Sciences, New Delhi, 110029, India.
Madhu RajeshwariDepartment of Pathology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, 110029, India.
Arvind KairoDepartment of Otolaryngology and Head and Neck Surgery, All India Institute of Medical Sciences, New Delhi, 110029, India.
Mehar C SharmaDepartment of Pathology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, 110029, India.
All India Institute of Medical Sciences · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A spectrum of mesenchymal neoplasms occur in the sinonasal region. One of these is solitary fibrous tumor (SFT), a translocation-associated neoplasm characterized by NAB2-STAT6 gene fusion. Sinonasal SFTs characteristically display CD34 immunopositivity, which aids in diagnosis. However, a small proportion of SFTs may be negative for CD34, making diagnosis difficult. The availability of STAT6 immunohistochemistry (IHC) has helped to overcome this. Malignant SFTs, characterized by increased cellularity and mitoses > 4 per ten high power fields, are extremely unusual in the sinonasal region, with only ten such cases reported to date. We report a case of a CD34-negative malignant SFT that was diagnosed using STAT6 IHC and confirmed by demonstrating NAB2 ex 4-STAT6 ex 2 fusion, and recurred 8 months after complete excision, to highlight the aggressive nature of this tumor.

Indexed as

Aged, 80 and overAntigens, CD34Biomarkers, TumorHumansImmunohistochemistryMaleNeoplasm Recurrence, LocalNose NeoplasmsOncogene Proteins, FusionRepressor ProteinsSolitary Fibrous TumorsSTAT6 Transcription FactorAntigens, CD34Biomarkers, TumorNAB2 protein, humanOncogene Proteins, FusionRepressor ProteinsSTAT6 protein, humanSTAT6 Transcription FactorHemangiopericytomaNoseSolitary fibrous tumorSpindle cell tumorSTAT6

Identifiers

PMID30623305
PMCPMC7021867
OpenAlexW2910840144

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.