Evidence map›Paper›PMID 30623035›Full record

ArticleHealth science reports2018

Angiotensin-1-converting enzyme inhibition, antioxidant activity, and modulation of cerebral Na+/K+ ATPase by free phenolics of African locust bean (Parkia biglobosa).

Kayode Komolafe, Afolabi C Akinmoladun, Titilope R Komolafe, Mary T Olaleye, Aline A Boligon, Akintunde A Akindahunsi, Joao B T Rocha

Open access · hybridAbstract read
In one paragraph

Article in Health science reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 11 citations in OpenAlex.

  1. Contemporary Insights into the Biological Mechanisms ofInternational journal of environmental research and public health · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Kayode KomolafeDepartment of Biochemistry, School of Sciences The Federal University of Technology Akure Nigeria.ORCID 0000-0003-3319-5863
Afolabi C AkinmoladunDepartment of Biochemistry, School of Sciences The Federal University of Technology Akure Nigeria.
Titilope R KomolafeDepartment of Biochemistry, School of Sciences The Federal University of Technology Akure Nigeria.
Mary T OlaleyeDepartment of Biochemistry, School of Sciences The Federal University of Technology Akure Nigeria.
Aline A BoligonDepartment of Biochemistry and Molecular Biology, CCNE Federal University of Santa Maria Santa Maria RS Brazil.
Akintunde A AkindahunsiDepartment of Biochemistry, School of Sciences The Federal University of Technology Akure Nigeria.
Joao B T RochaDepartment of Biochemistry and Molecular Biology, CCNE Federal University of Santa Maria Santa Maria RS Brazil.
Federal University of Technology · NGUniversidade Federal de Santa Maria · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsTo investigate the antioxidant activities and effects of free phenols (FPPB) and bound phenols (BPPB) of Parkia biglobosa leaves on some enzymes of neuro-cardiovascular relevance. METHODS AND

resultsHPLC-DAD fingerprinting of FPPB and BPPB, and the antihemolytic, radical (1,1-diphenyl-2 picrylhydrazyl, DPPH; 2,2-azino-bis(3-ethylbenzthiazoline-6-sulphonic acid), ABTS) scavenging and ferric reducing antioxidant properties of extracts, were assessed. In addition, the effects of the phenolics on angiotensin-1-converting enzyme (ACE), cerebral acetylcholinesterase/butyrylcholinesterase (AChE/BuChE), and Na

conclusionThe effects of P biglobosa on ACE and cerebral ATPase are related to its constituent phenolics. ACE inhibition could be an important mechanism underlying the documented hypotensive effect of the plant.

Indexed as

angiotensin‐converting enzymehypotensiveP biglobosaphenolics

Identifiers

PMID30623035
PMCPMC6266567
OpenAlexW2769563111

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.