ReviewJournal of immunology research2018
Zinc in Keratinocytes and Langerhans Cells: Relevance to the Epidermal Homeostasis.
Review in Journal of immunology research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 38 citations in OpenAlex.
- Skin-inspired phototherapeutic cryogel ameliorates infected wound healing by orchestrating mechanotransduction and immunomodulation.Bioactive materials · 2026Article
- Article
- Gait, skin and coat, and plasma cytokine changes in response to exercise and trace mineral source.Journal of animal science · 2026Article
- Feeding the Skin Barrier: The Impact of Macro- and Micronutrients on Skin Barrier Function.Clinical and translational allergy · 2025Review
- Effect of Supplemental Trace Mineral Source on Haircoat and Hair Loss in Adult Cats.Animals : an open access journal from MDPI · 2025Article
- A Novel Butyrate Derivative, Zinc Dibutyroyllysinate, Blunts Microphthalmia-Associated Transcription Factor Expression and Up-Regulates Retinol and Differentiation Pathway mRNAs in a Full-Thickness Human Skin Model.International journal of molecular sciences · 2025Article
- Effect of Supplemental Trace Mineral Source on Haircoat and Activity Levels in Senior Dogs.Animals : an open access journal from MDPI · 2025Article
- Zinc, Copper, and Iron in Selected Skin Diseases.International journal of molecular sciences · 2024Review
- Zinc finger protein 33B demonstrates sex interaction with atopy-related markers in childhood asthma.The European respiratory journal · 2023Article
- Zinc and Zinc Transporters in Dermatology.International journal of molecular sciences · 2022Review
- Article
- Edible bird's nest, an Asian health food supplement, possesses anti-inflammatory responses in restoring the symptoms of atopic dermatitis: An analysis of signaling cascades.Frontiers in pharmacology · 2022Article
- Electrospun Poly(ethylene Terephthalate)/Silk Fibroin Composite for Filtration Application.Polymers · 2021Article
- Zinc in Dog Nutrition, Health and Disease: A Review.Animals : an open access journal from MDPI · 2021Review
- Assessment of cytotoxicity and antioxidant properties of berry leaves as by-products with potential application in cosmetic and pharmaceutical products.Scientific reports · 2021Article
- Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the skin, the epidermis is continuously exposed to various kinds of external substances and stimuli. Therefore, epidermal barriers are crucial for providing protection, safeguarding health, and regulating water balance by maintaining skin homeostasis. Disruption of the epidermal barrier allows external substances and stimuli to invade or stimulate the epidermal cells, leading to the elicitation of skin inflammation. The major components of the epidermal barrier are the stratum corneum (SC) and tight junctions (TJs). The presence of zinc in the epidermis promotes epidermal homeostasis; hence, this study reviewed the role of zinc in the formation and function of the SC and TJs. Langerhans cells (LCs) are one of the antigen-presenting cells found in the epidermis. They form TJs with adjacent keratinocytes (KCs), capture external antigens, and induce antigen-specific immune reactions. Thus, the function of zinc in LCs was examined in this review. We also summarized the general knowledge of zinc and zinc transporters in the epidermis with updated findings.
Indexed as
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.