Evidence map›Paper›PMID 30622793›Full record

ArticleJournal of thoracic disease2018

Circulating exosomal miR-92b-5p is a promising diagnostic biomarker of heart failure with reduced ejection fraction patients hospitalized for acute heart failure.

Tao Wu, Yichen Chen, Yantao Du, Jin Tao, Wei Li, Zhong Zhou, Zhuo Yang

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of thoracic disease, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed, 5 pooled it
3.8field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 5 syntheses or guidelines pooled it, 62 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Exploration of Potential Genetic Biomarkers for Heart Failure: A Systematic Review.International journal of environmental research and public health · 2021
    Pooled it
  5. The Role of microRNAs in Heart Failure: A Systematic Review.Frontiers in cardiovascular medicine · 2020
    Pooled it
  6. Review
  7. Review
  8. Review
  9. Review
  10. Review
  11. Review
  12. Endosomal Mechanisms in Heart Failure Pathophysiology.Current heart failure reports · 2025
    Review
  13. Review
  14. Article
  15. Exploring the landscape of exosomes in heart failure: a bibliometric analysis.International journal of surgery (London, England) · 2025
    Review
  16. Review
  17. Review
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Tao WuDepartment of Cardiovascular, the Affiliated Hospital of Medical School of Ningbo University, Ningbo 315020, China.
Yichen ChenNingbo Institute of Medical Science, Ningbo 315020, China.
Yantao DuNingbo Institute of Medical Science, Ningbo 315020, China.
Jin TaoZhejiang Pharmaceutical College, Ningbo 315000, China.
Wei LiNingbo Emergency Medical Center, Ningbo 315020, China.
Zhong ZhouDepartment of Cardiovascular, the Affiliated Hospital of Medical School of Ningbo University, Ningbo 315020, China.
Zhuo YangDepartment of Cardiovascular, the Affiliated Hospital of Medical School of Ningbo University, Ningbo 315020, China.
Ningbo University · CNNingbo Academy of Agricultural Sciences · CNZhejiang Pharmaceutical College · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCirculating microRNA (miRNA) biomarkers have been extensively reported in cardiovascular diseases (CVDs). However, serum exosomal miRNA (exo-miRNA) as biomarker in patients with heart failure (HF) with reduced ejection fraction (HFrEF) remain largely unexplored. We sought to investigate the potential of three types of serum exo-miRNAs as biomarkers for diagnosis in HFrEF patients who were admitted in hospital because of acute heart failure (AHF).

methodsA total of 28 HFrEF patients hospitalized for AHF, including

resultsThe particle size was confirmed as 40-150 nm using NaNOZS-90 and transmission electron microscopy. Exosomal biomarkers CD63 and Hsp70 were readily detected. The expression level of serum exo-miRNAs were transformed into log2

conclusionsExo-miR-92b-5p levels in the serum may serve as a marker for HFrEF diagnosis.

Indexed as

Acute heart failure (AHF)circulatingdiagnostic biomarkerexosomeheart failure with reduced ejection fraction (HFrEF)miR-92b-5p

Identifiers

PMID30622793
PMCPMC6297406
OpenAlexW2899041651

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.