Evidence map›Paper›PMID 30622700›Full record

ArticlePulmonary circulation

Retinal vascular changes and right ventricular structure and function: the MESA-Right Ventricle and MESA-Eye studies.

Anthony C Chyou, Barbara E K Klein, Ronald Klein, R Graham Barr, Mary Frances Cotch, Amy Praestgaard, Tien Y Wong, Joao Lima, David A Bluemke, Steven Kawut

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pulmonary circulation. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.9field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Beyond the Lungs: Systemic Manifestations of Pulmonary Arterial Hypertension.American journal of respiratory and critical care medicine · 2020
    Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 8 institutions in 2 countries.

Anthony C ChyouDivision of Cardiology and the Department of Medicine, Weill Cornell Medical College, New York Presbyterian Hospital, New York City, NY, USA.
Barbara E K KleinDepartment of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Ronald KleinDepartment of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
R Graham BarrDepartment of Medicine, Columbia University College of Physicians and Surgeons, New York City, NY, USA.
Mary Frances CotchNational Eye Institute, National Institutes of Health, Bethesda, MD, USA.
Amy PraestgaardCenter for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Tien Y WongSingapore Eye Research Institute, National University of Singapore, Singapore, Republic of Singapore.
Joao LimaDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
David A BluemkeNational Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD, USA.
Steven KawutCenter for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
University of Pennsylvania · USUniversity of Wisconsin–Madison · USColumbia University · USCornell University · USJohns Hopkins Medicine · USNational Eye Institute · USNational Institutes of Health · USSingapore Eye Research Institute · SG

Funding

Endothelial Dysfunction and the RV in the Multi-Ethnic Study of AtherosclerosisR01HL086719 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI KAWUT, STEVEN M · 2007 to 2010
$2.0M
Multi-ethnic Study Of Atherosclerosis - Vision ComponentZIAEY000403 · NEI · NATIONAL EYE INSTITUTE · PI COTCH, MARY FRANCES · 2009 to 2020
$1.8M
Mentored Patient-Oriented Research in Pulmonary Arterial HypertensionK24HL103844 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI KAWUT, STEVEN M · 2011 to 2020
$1.6M
NHLBI NIH HHS K24 HL103844NHLBI NIH HHS R01 HL086719
6 · The paper itself

Abstract

Retinal vessel diameters have been associated with left ventricular morphology and function but their relationship with the right ventricle (RV) has not been studied. We hypothesized that wider retinal venules and narrower retinal arterioles are associated with RV morphology and function. RV end-diastolic mass (RVEDM), end-diastolic volume (RVEDV), end-systolic volume (RVESV), stroke volume (RVSV), and ejection fraction (RVEF) were assessed using cardiac magnetic resonance imaging (MRI) scans of 4204 participants without clinical cardiovascular disease at the baseline examination; retinal photography was obtained at the second examination. Mean diameters of retinal arterioles and venules were measured and summarized as central retinal vein and artery equivalents ("veins" and "arteries," respectively). After adjusting for covariates, wider veins were associated with greater RVEDM and RVEDV in women (

Indexed as

pulmonary hypertensionretinal vasculatureright ventricle

Identifiers

PMID30622700
PMCPMC6304712
OpenAlexW2902041055

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.