ArticleCell & bioscience2019
The first structure of HIV-1 gp120 with CD4 and CCR5 receptors.
Article in Cell & bioscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- The Role of the CCR5 Receptor in Neuropathic Pain Modulation: Current Insights and Therapeutic Implications.Biomedicines · 2025Review
- Quantifying Impact of HIV Receptor Surface Density Reveals Differences in Fusion Dynamics of HIV Strains.Viruses · 2025Article
- Gnawing Between Cells and Cells in the Immune System: Friend or Foe? A Review of Trogocytosis.Frontiers in immunology · 2022Review
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Shaik et al. recently published online the cryo-electron microscopy structure of HIV-1 gp120 in complex with CD4 and CCR5 receptors. This is the first structure of the ternary HIV-1 gp120/CD4/CCR5 complex. This breakthrough of Env structure provides insights into HIV-1 fusion mechanism, CCR5 function, co-receptor switch, and, most importantly, the development of co-receptor-targeted therapeutic inhibitor and HIV-1 vaccine. It also shed lights on the immunogenicity of gp120 by revealing the stably exposed conserved gp41-interactive region of gp120 in the complex.
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Registered trials
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