Evidence map›Paper›PMID 30622671›Full record

ArticleOxidative medicine and cellular longevity2018

MicroRNA miR-24-3p Reduces Apoptosis and Regulates Keap1-Nrf2 Pathway in Mouse Cardiomyocytes Responding to Ischemia/Reperfusion Injury.

Xu Xiao, Zhigang Lu, Victor Lin, Adam May, Daniel H Shaw, Zhihao Wang, Briana Che, Kyle Tran, Hongjun Du, Peter X Shaw

Open access · hybridAbstract read
In one paragraph

Article in Oxidative medicine and cellular longevity, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers.

0numbers the graph read from it
0cells of the map it votes in
77citing papers in PubMed
5.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

77 citing papers in PubMed, 141 citations in OpenAlex.

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  18. NRF2, a Superstar of Ferroptosis.Antioxidants (Basel, Switzerland) · 2023
    Review
  19. Regulatory effects of trimetazidine in cardiac ischemia/reperfusion injury.Naunyn-Schmiedeberg's archives of pharmacology · 2023
    Review
  20. Article

17 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Xu XiaoDepartment of Emergency Medicine, Sichuan Provincial People's Hospital, Chengdu, Sichuan, China.ORCID 0000-0003-2173-505X
Zhigang LuDepartment of Ophthalmology and Altman Clinical and Translational Research Institute, University of California San Diego, La Jolla, CA, USA.
Victor LinDepartment of Ophthalmology and Altman Clinical and Translational Research Institute, University of California San Diego, La Jolla, CA, USA.ORCID 0000-0003-4948-1979
Adam MayDepartment of Ophthalmology and Altman Clinical and Translational Research Institute, University of California San Diego, La Jolla, CA, USA.
Daniel H ShawDepartment of Ophthalmology and Altman Clinical and Translational Research Institute, University of California San Diego, La Jolla, CA, USA.
Zhihao WangDepartment of Ophthalmology and Altman Clinical and Translational Research Institute, University of California San Diego, La Jolla, CA, USA.
Briana CheDepartment of Ophthalmology and Altman Clinical and Translational Research Institute, University of California San Diego, La Jolla, CA, USA.
Kyle TranDepartment of Ophthalmology and Altman Clinical and Translational Research Institute, University of California San Diego, La Jolla, CA, USA.
Hongjun DuDepartment of Ophthalmology, Xijing Hospital, Xi'an, China.
Peter X ShawDepartment of Ophthalmology and Altman Clinical and Translational Research Institute, University of California San Diego, La Jolla, CA, USA.ORCID 0000-0001-7392-6224
University of California San Diego · USFairview School District · USXijing Hospital · CN

Funding

HTRA1 as a Therapeutic Target in the Treatment of Wet AMDR01EY025693 · NEI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SHAW, PETER X · 2015 to 2019
$1.8M
NEI NIH HHS R01 EY025693
6 · The paper itself

Abstract

In recent years, microRNAs (miRNAs) have received increasing attention for their role in ischemia/reperfusion injury (I/RI), and many miRNAs have been demonstrated to play a very important role in cardiac I/RI. The miRNA miR-24-3p is a tumor suppressor that regulates multiple tumors; however, it remains unclear whether the expression level of miR-24-3p is altered in cardiac cells under I/RI. In this study, we used mouse primary cardiomyocytes and the H9C2 cardiomyocyte cell line to perform

Indexed as

AnimalsApoptosisKelch-Like ECH-Associated Protein 1MiceMice, Inbred C57BLMicroRNAsMyocardial Reperfusion InjuryMyocytes, CardiacNF-E2-Related Factor 2TransfectionKeap1 protein, mouseKelch-Like ECH-Associated Protein 1MicroRNAsMirn24 microRNA, mouseNfe2l2 protein, mouseNF-E2-Related Factor 2

Identifiers

PMID30622671
PMCPMC6304907
OpenAlexW2902643104

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.