Evidence map›Paper›PMID 30622667›Full record

ArticleOxidative medicine and cellular longevity2018

Oxidative Stress in Women Treated with Atosiban for Impending Preterm Birth.

Mariusz Grzesiak, Zuzanna Gaj, Rafał Kocyłowski, Joanna Suliburska, Przemysław Oszukowski, Wojciech Horzelski, Constantin von Kaisenberg, Maciej Banach

Open access · hybridAbstract read
In one paragraph

Article in Oxidative medicine and cellular longevity, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.1field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 21 citations in OpenAlex.

  1. Comparison of Intratympanic Oxytocin and Dexamethasone in Cisplatin Ototoxicity: An Experimental Study.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2024
    Article
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  5. Is Oxytocin "Nature's Medicine"?Pharmacological reviews · 2020
    Review
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 2 countries.

Mariusz GrzesiakDepartment of Obstetrics, Perinatology and Gynecology, Polish Mother's Memorial Hospital-Research Institute, Lodz 93-338, Poland.ORCID 0000-0002-6900-4347
Zuzanna GajDepartment of Obstetrics, Perinatology and Gynecology, Polish Mother's Memorial Hospital-Research Institute, Lodz 93-338, Poland.ORCID 0000-0002-1803-1935
Rafał KocyłowskiDepartment of Obstetrics, Perinatology and Gynecology, Polish Mother's Memorial Hospital-Research Institute, Lodz 93-338, Poland.ORCID 0000-0003-4094-7103
Joanna SuliburskaInstitute of Human Nutrition and Dietetics, Poznan University of Life Sciences, Poznan 60-624, Poland.ORCID 0000-0002-0937-8427
Przemysław OszukowskiDepartment of Obstetrics and Perinatology, Medical University of Lodz, Zgierz 95-100, Poland.ORCID 0000-0003-0306-0239
Wojciech HorzelskiFaculty of Mathematics and Computer Science, University of Lodz, Lodz 90-238, Poland.ORCID 0000-0002-3690-5368
Constantin von KaisenbergDepartment of Obstetrics and Gynecology, Hannover Medical School, Hannover 30625, Germany.ORCID 0000-0001-5554-1937
Maciej BanachDepartment of Hypertension, Medical University of Lodz, Lodz 90-549, Poland.ORCID 0000-0001-6690-6874
Polish Mother’s Memorial Hospital Research Institute · PLMedical University of Lodz · PLMedizinische Hochschule Hannover · DEUniversity of Life Sciences in Poznań · PLUniversity of Łódź · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Preterm birth is defined as delivery before 37 completed weeks of pregnancy, and it is the leading cause of neonatal morbidity and mortality. Oxidative stress is recognized as an important factor in the pathogenesis of premature labor. We conducted this analysis to investigate the safety of administration of the tocolytic drug Atosiban-a reversible, competitive antagonist of the oxytocin receptor in the treatment of preterm birth and its impact on the level of oxidative stress in pregnant women after 48 hours of tocolytic treatment. This prospective study was conducted between March 2016 and August 2017 at the Obstetric Clinic of the Polish Mother's Memorial Hospital Research Institute. Total oxidant status (TOS), total antioxidant status (TAS), and oxidative stress index (OSI) values as well as 3-nitrotyrosine, carbonyl, and thiol group levels were measured using an ELISA test in serum and plasma of 56 pregnant women before and after 48 hours of continuous administration of Atosiban. We found that TAS levels decreased almost twice after the 48-hour drug administration (0.936 ± 0.360 mmol/L vs. 0.582 ± 0.305 mmol/L,

Indexed as

AdultFemaleHormone AntagonistsHumansInfant, NewbornOxidative StressPremature BirthRetrospective StudiesVasotocinatosibanHormone AntagonistsVasotocin

Identifiers

PMID30622667
PMCPMC6304866
OpenAlexW2903270686

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.