ReviewEvolutionary applications2019
Deleterious alleles in the context of domestication, inbreeding, and selection.
Review in Evolutionary applications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 83 papers.
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Who cites it
83 citing papers in PubMed.
- Genetic diversity of Caracu cattle reveals contrasting trends between general and closed populations.Tropical animal health and production · 2026Article
- Genome-Wide Differentiation, Inbreeding, and Candidate Selection Loci in Local Vietnamese Pig Breeds.International journal of molecular sciences · 2026Article
- Unknown Biases: Understanding How Anthropogenic Hybridization Impacts Genomic Diversity and Demographic Estimates.Animals : an open access journal from MDPI · 2026Article
- Inherited Disorders and Disease-Resistance Genomics in Kazakhstan Ruminants: Evidence, Limits and Breeding Priorities.International journal of molecular sciences · 2026Review
- Genomic partitioning and functional dissection of inbreeding depression for stature in Brown Swiss cattle.Genetics, selection, evolution : GSE · 2026Article
- Reduced Genetic Load and Inbreeding in Reintroduced African Wild Dogs Reflect the Benefits of Admixture.Molecular ecology · 2026Article
- Genomic erosion across avian lineages in the context of their evolutionary history.Molecular biology and evolution · 2026Article
- Harnessing Deep Learning in Searching Wild Relatives of Domestic Animals.Molecular ecology resources · 2026Article
- Increased Genetic Load in Breed Chickens and Reduced Coding Content in Long ROH.Genome biology and evolution · 2026Article
- Framework for assessing genetic variation in livestock using demographic, pedigree, and genomic measures.Frontiers in genetics · 2026Review
- Characterization of genomic diversity and population structure of worldwide Duroc subpopulations and other pig breeds.Genetics, selection, evolution : GSE · 2025Article
- Breeding objectives, production systems and trait preferences of indigenous Tswana sheep farmers in Botswana: inputs towards community based breeding programs.Tropical animal health and production · 2025Article
- GWAS for behavioral traits in golden retrievers identifies genes implicated in human temperament, mental health, and cognition.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Unveiling the significance of dog domestication in cognitive dysfunction: Are wolves protected?Open veterinary journal · 2025Article
- That's So Last Season: Unraveling the Genomic Consequences of Fur Farming in Arctic Foxes (Vulpes lagopus).Molecular ecology · 2025Article
- Assessing genetic gain and diversity in Ethiopian bread wheat across six decades.Scientific reports · 2025Article
- Unraveling genetic diversity and population structure of pineapple germplasm using genome-wide SNP markers.Molecular genetics and genomics : MGG · 2025Article
- Dynamics of Deleterious Mutations and Purifying Selection in Small Population Isolates.Molecular biology and evolution · 2025Article
- Multi-dimensional annotation of porcine variants using genomic and epigenomic features in pigs.BMC biology · 2025Article
- Population size interacts with reproductive longevity to shape the germline mutation rate.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
23 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Each individual has a certain number of harmful mutations in its genome. These mutations can lower the fitness of the individual carrying them, dependent on their dominance and selection coefficient. Effective population size, selection, and admixture are known to affect the occurrence of such mutations in a population. The relative roles of demography and selection are a key in understanding the process of adaptation. These are factors that are potentially influenced and confounded in domestic animals. Here, we hypothesize that the series of events of bottlenecks, introgression, and strong artificial selection associated with domestication increased mutational load in domestic species. Yet, mutational load is hard to quantify, so there are very few studies available revealing the relevance of evolutionary processes. The precise role of artificial selection, bottlenecks, and introgression in further increasing the load of deleterious variants in animals in breeding and conservation programmes remains unclear. In this paper, we review the effects of domestication and selection on mutational load in domestic species. Moreover, we test some hypotheses on higher mutational load due to domestication and selective sweeps using sequence data from commercial pig and chicken lines. Overall, we argue that domestication by itself is not a prerequisite for genetic erosion, indicating that fitness potential does not need to decline. Rather, mutational load in domestic species can be influenced by many factors, but consistent or strong trends are not yet clear. However, methods emerging from molecular genetics allow discrimination of hypotheses about the determinants of mutational load, such as effective population size, inbreeding, and selection, in domestic systems. These findings make us rethink the effect of our current breeding schemes on fitness of populations.
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