Evidence map›Paper›PMID 30622534›Full record

ArticleFrontiers in immunology2018

A Computational Approach Identifies Immunogenic Features of Prognosis in Human Cancers.

Malini Manoharan, Nitin Mandloi, Sushri Priyadarshini, Ashwini Patil, Rohit Gupta, Laxman Iyer, Ravi Gupta, Amitabha Chaudhuri

Open access · goldAbstract readEvaluation StudyValidation Study
In one paragraph

Article in Frontiers in immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.3field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Malini ManoharanMedGenome Labs Ltd., Bangalore, India.
Nitin MandloiMedGenome Labs Ltd., Bangalore, India.
Sushri PriyadarshiniMedGenome Labs Ltd., Bangalore, India.
Ashwini PatilMedGenome Inc., Foster City, CA, United States.
Rohit GuptaMedGenome Labs Ltd., Bangalore, India.
Laxman IyerMedGenome Labs Ltd., Bangalore, India.
Ravi GuptaMedGenome Labs Ltd., Bangalore, India.
Amitabha ChaudhuriMedGenome Inc., Foster City, CA, United States.
SciGenom Labs (India) · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A large number of tumor intrinsic and extrinsic factors determine long-term survival in human cancers. In this study, we stratified 9120 tumors from 33 cancers with respect to their immune cell content and identified immunogenomic features associated with long-term survival. Our analysis demonstrates that tumors infiltrated by CD8

Indexed as

Antigens, CDAntineoplastic Agents, ImmunologicalCD8-Positive T-LymphocytesComputational BiologyCTLA-4 AntigenDatasets as TopicGene Expression ProfilingGene Expression Regulation, NeoplasticHepatitis A Virus Cellular Receptor 2HumansKaplan-Meier EstimateLymphocyte Activation Gene 3 ProteinLymphocytes, Tumor-InfiltratingNeoplasmsPatient SelectionPhosphatidylinositol 3-KinasesAntigens, CDAntineoplastic Agents, ImmunologicalCTLA-4 AntigenCTLA4 protein, humanHAVCR2 protein, humanHepatitis A Virus Cellular Receptor 2Lag3 protein, humanLymphocyte Activation Gene 3 ProteinPDCD1 protein, humanPhosphatidylinositol 3-KinasesProgrammed Cell Death 1 Receptoranergic and exhausted T cells and prognosisCD8+ T cell infiltrationgene signaturesinflamed tumorsTCR signalingtumor microenvironment

Identifiers

PMID30622534
PMCPMC6308325
OpenAlexW2906554396

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.