Evidence map›Paper›PMID 30622478›Full record

ArticleFrontiers in physiology2018

Pharmacological Modulation of Mitochondrial Ca

Shanna Hamilton, Radmila Terentyeva, Tae Yun Kim, Peter Bronk, Richard T Clements, Jin O-Uchi, György Csordás, Bum-Rak Choi, Dmitry Terentyev

Open access · goldAbstract read
In one paragraph

Article in Frontiers in physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 55 citations in OpenAlex.

  1. Article
  2. Restoration of mitochondrial CaJournal of molecular and cellular cardiology · 2026
    Article
  3. Mitochondrial CaCommunications biology · 2026
    Article
  4. Article
  5. Article
  6. Review
  7. Increased Intermembrane Space [CaCirculation research · 2025
    Article
  8. Article
  9. Article
  10. Growth-Associated Protein-43 Loss Promotes CaAntioxidants (Basel, Switzerland) · 2025
    Article
  11. Mitochondrial dysfunction as a central hub linking NaFrontiers in cardiovascular medicine · 2025
    Review
  12. Article
  13. Article
  14. Review
  15. Distinct Effects of Mitochondrial NaJournal of the American Heart Association · 2023
    Article
  16. Article
  17. Cardioprotective Properties of Kaempferol: A Review.Plants (Basel, Switzerland) · 2023
    Review
  18. Article
  19. The mitochondrial CabioRxiv : the preprint server for biology · 2023
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Shanna HamiltonDepartment of Medicine, The Warren Alpert Medical School of Brown University, Rhode Island Hospital, Cardiovascular Research Center, Providence, RI, United States.
Radmila TerentyevaDepartment of Medicine, The Warren Alpert Medical School of Brown University, Rhode Island Hospital, Cardiovascular Research Center, Providence, RI, United States.
Tae Yun KimDepartment of Medicine, The Warren Alpert Medical School of Brown University, Rhode Island Hospital, Cardiovascular Research Center, Providence, RI, United States.
Peter BronkDepartment of Medicine, The Warren Alpert Medical School of Brown University, Rhode Island Hospital, Cardiovascular Research Center, Providence, RI, United States.
Richard T ClementsDepartment of Surgery, The Warren Alpert Medical School of Brown University, Rhode Island Hospital, Cardiovascular Research Center, Providence, RI, United States.
Jin O-UchiLillehei Heart Institute University of Minnesota, Cancer and Cardiovascular Research Building, Minneapolis, MN, United States.
György CsordásDepartment of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA, United States.
Bum-Rak ChoiDepartment of Medicine, The Warren Alpert Medical School of Brown University, Rhode Island Hospital, Cardiovascular Research Center, Providence, RI, United States.
Dmitry TerentyevDepartment of Medicine, The Warren Alpert Medical School of Brown University, Rhode Island Hospital, Cardiovascular Research Center, Providence, RI, United States.
Rhode Island Hospital · USBrown University · USThomas Jefferson University · USUniversity of Minnesota · US

Funding

Research CoreP30GM114750 · NIGMS · WOMEN AND INFANTS HOSPITAL-RHODE ISLAND · PI SHAW, SUNIL K · 2015 to 2019
$4.5M
Structural-functional zoning of the mitochondrion in cardiac Ca2+, ROS, and energetics regulationR01HL142864 · NHLBI · THOMAS JEFFERSON UNIVERSITY · PI CSORDAS, GYORGY, SHEU, SHEY-SHING · 2018 to 2021
$2.5M
REgulation of Calcium Homeostasis by MyomiRs in Heart FailureR01HL121796 · NHLBI · RHODE ISLAND HOSPITAL · PI TERENTYEV, DMITRY A · 2015 to 2019
$2.0M
Surgical Cardioprotection Through BKCa-Dependent Modulation of Mitochondrial SupercomplexesR01HL135236 · NHLBI · UNIVERSITY OF RHODE ISLAND · PI CLEMENTS, RICHARD T · 2018 to 2021
$1.9M
Regulation of mitochondrial calcium uniporter in the heartR01HL136757 · NHLBI · UNIVERSITY OF MINNESOTA · PI O-UCHI, JIN · 2017 to 2021
$1.9M
The role of dynamic changes in repolarization and calcium transients in Long QT rR01HL096669 · NHLBI · RHODE ISLAND HOSPITAL · PI CHOI, BUM-RAK · 2009 to 2013
$1.9M
NHLBI NIH HHS R01 HL096669NHLBI NIH HHS R01 HL121796NHLBI NIH HHS R01 HL135236NHLBI NIH HHS R01 HL136757NHLBI NIH HHS R01 HL142864NIGMS NIH HHS P30 GM114750
6 · The paper itself

Abstract

In a physiological setting, mitochondria increase oxidative phosphorylation during periods of stress to meet increased metabolic demand. This in part is mediated via enhanced mitochondrial Ca

Indexed as

Ca2+-induced Ca2+ releasehypertrophymitochondriareactive oxygen speciesryanodine receptorventricular arrhythmia

Identifiers

PMID30622478
PMCPMC6308295
OpenAlexW2906229934

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.