ArticleFrontiers in neuroinformatics2018
National Neuroinformatics Framework for Canadian Consortium on Neurodegeneration in Aging (CCNA).
Article in Frontiers in neuroinformatics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed.
- Sex differences in the association of adverse childhood experiences with brain and cognition along a continuum of risk for Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Cerebral small vessel disease and cognition in older adults across the neurodegenerative spectrum: insights from the COMPASS-ND study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Peripheral inflammation in a Canadian cohort of neurodegenerative conditions: Occurrence, determinants, and impact.Journal of Alzheimer's disease : JAD · 2026Article
- Thyroid function and cognitive health: rethinking the relationship between "suboptimal" TSH/FT4 levels and cognitive decline.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Psychosocial Function in Mild Cognitive Impairment: Social Participation is Associated With Cognitive Performance in Multiple Domains.Journal of applied gerontology : the official journal of the Southern Gerontological Society · 2025Article
- The effect of hearing ability on dual-task performance following multi-domain training in older adults with mild cognitive impairment: findings from the SYNERGIC trial.Frontiers in aging neuroscience · 2025Article
- Hearing loss is associated with decreased default-mode network connectivity in individuals with mild cognitive impairment.Neuroimage. Reports · 2023Article
- Detecting conversion from mild cognitive impairment to Alzheimer's disease using FLAIR MRI biomarkers.NeuroImage. Clinical · 2023Article
- Alzheimer's and vascular disease classification using regional texture biomarkers in FLAIR MRI.NeuroImage. Clinical · 2023Article
- Synthesis of diffusion-weighted MRI scalar maps from FLAIR volumes using generative adversarial networks.Frontiers in neuroinformatics · 2023Article
- Cross-sectional and longitudinal Biomarker extraction and analysis for multicentre FLAIR brain MRI.Neuroimage. Reports · 2022Article
- FLAIR MRI biomarkers of the normal appearing brain matter are related to cognition.NeuroImage. Clinical · 2022Article
- Segmentation of white matter lesions in multicentre FLAIR MRI.Neuroimage. Reports · 2021Article
- Intracranial volume segmentation for neurodegenerative populations using multicentre FLAIR MRI.Neuroimage. Reports · 2021Article
- Automated Midline Estimation for Symmetry Analysis of Cerebral Hemispheres in FLAIR MRI.Frontiers in aging neuroscience · 2021Article
- Integration ofFrontiers in neuroinformatics · 2018Article
- Biological sex and bilingualism: Its impact on risk and resilience for dementia.Alzheimer's & dementia (Amsterdam, Netherlands)Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Canadian Institutes for Health Research (CIHR) launched the "International Collaborative Research Strategy for Alzheimer's Disease" as a signature initiative, focusing on Alzheimer's Disease (AD) and related neurodegenerative disorders (NDDs). The Canadian Consortium for Neurodegeneration and Aging (CCNA) was subsequently established to coordinate and strengthen Canadian research on AD and NDDs. To facilitate this research, CCNA uses LORIS, a modular data management system that integrates acquisition, storage, curation, and dissemination across multiple modalities. Through an unprecedented national collaboration studying various groups of dementia-related diagnoses, CCNA aims to investigate and develop proactive treatment strategies to improve disease prognosis and quality of life of those affected. However, this constitutes a unique technical undertaking, as heterogeneous data collected from sites across Canada must be uniformly organized, stored, and processed in a consistent manner. Currently clinical, neuropsychological, imaging, genomic, and biospecimen data for 509 CCNA subjects have been uploaded to LORIS. In addition, data validation is handled through a number of quality control (QC) measures such as double data entry (DDE), conflict flagging and resolution, imaging protocol checks, and visual imaging quality validation. Site coordinators are also notified of incidental findings found in MRI reads or biosample analyses. Data is then disseminated to CCNA researchers via a web-based Data-Querying Tool (DQT). This paper will detail the wide array of capabilities handled by LORIS for CCNA, aiming to provide the necessary neuroinformatic infrastructure for this nation-wide investigation of healthy and diseased aging.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.