Evidence map›Paper›PMID 30622435›Full record

ArticleMediators of inflammation2018

Effects of Tobacco Usage and Antiretroviral Therapy on Biomarkers of Systemic Immune Activation in HIV-Infected Participants.

Helen C Steel, W D Francois Venter, Annette J Theron, Ronald Anderson, Charles Feldman, Luyanda Kwofie, Tanita Cronjé, Natasha Arullapan, Theresa M Rossouw

Open access · goldAbstract read
In one paragraph

Article in Mediators of inflammation, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 19 citations in OpenAlex.

  1. Trial
  2. HIV-HPV interactions via extracellular vesicles among tobacco smokers and nonsmokers.Experimental biology and medicine (Maywood, N.J.) · 2025
    Article
  3. Article
  4. Article
  5. Article
  6. An Emerging Syndemic of Smoking and Cardiopulmonary Diseases in People Living with HIV in Africa.International journal of environmental research and public health · 2021
    Article
  7. Article
  8. Bidirectional Associations among Nicotine and Tobacco Smoke, NeuroHIV, and Antiretroviral Therapy.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2020
    Review
  9. Independent and Combined Effects of Nicotine or Chronic Tobacco Smoking and HIV on the Brain: A Review of Preclinical and Clinical Studies.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2020
    Review
  10. Review
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Helen C SteelDepartment of Immunology, University of Pretoria, South Africa.ORCID 0000-0001-5899-4472
W D Francois VenterWits Reproductive Health and HIV Institute, University of the Witwatersrand, South Africa.
Annette J TheronDepartment of Immunology, University of Pretoria, South Africa.
Ronald AndersonDepartment of Immunology, University of Pretoria, South Africa.ORCID 0000-0002-5925-6452
Charles FeldmanDivision of Pulmonology, Department of Internal Medicine, Charlotte Maxeke Johannesburg Academic Hospital and Faculty of Health Sciences, University of the Witwatersrand, South Africa.ORCID 0000-0002-6881-8314
Luyanda KwofieDepartment of Immunology, University of Pretoria, South Africa.
Tanita CronjéDepartment of Statistics, University of Pretoria, South Africa.ORCID 0000-0002-8861-4466
Natasha ArullapanWits Reproductive Health and HIV Institute, University of the Witwatersrand, South Africa.
Theresa M RossouwDepartment of Immunology, University of Pretoria, South Africa.ORCID 0000-0003-4066-922X
University of Pretoria · ZAUniversity of the Witwatersrand · ZANational Health Laboratory Service · ZA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Like HIV infection, smoking, which is common among HIV-infected persons, is associated with chronic, systemic inflammation. However, the possible augmentative effects of HIV infection and smoking and other types of tobacco usage on indices of systemic inflammation and the impact of combination antiretroviral therapy (cART) thereon remain largely unexplored and represent the focus of the current study. Of the total number of HIV-infected persons recruited to the study (

Indexed as

Anti-HIV AgentsAnti-Retroviral AgentsAntiretroviral Therapy, Highly ActiveBiomarkersC-Reactive ProteinHIV InfectionsHumansInterleukin-6Interleukin-8NicotianaAnti-HIV AgentsAnti-Retroviral AgentsBiomarkersC-Reactive ProteinInterleukin-6Interleukin-8

Identifiers

PMID30622435
PMCPMC6304812
OpenAlexW2905318721

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.