ArticleInternational journal of obesity (2005)2019
Differential SLC6A4 methylation: a predictive epigenetic marker of adiposity from birth to adulthood.
Article in International journal of obesity (2005), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 41 citations in OpenAlex.
- Associations between dietary patterns, eating behaviours, and body composition and adiposity in 3-year-old children of mothers with obesity.Pediatric obesity · 2020Trial
- Nutrition in early life, epigenetics and lifelong health - evidence from cohort and intervention studies.The Proceedings of the Nutrition Society · 2025Review
- The role of mother-infant interaction and infant temperament in predicting the rate of post-NICU physical development in low birth weight infants: a prospective cohort study.BMC pregnancy and childbirth · 2025Article
- Sex dimorphic associations of Prader-Willi imprinted gene expressions in umbilical cord with prenatal and postnatal growth in healthy infants.World journal of pediatrics : WJP · 2025Article
- Nutritional Influences on Adiposity Rebound and Cardiometabolic Outcomes in a Prospective Birth Cohort of Low-Birth-Weight Children: A Study Protocol.Wellcome open research · 2025Article
- Newborn adiposity is associated with cord blood DNA methylation at IGF1R and KLF7.Obesity (Silver Spring, Md.) · 2024Article
- Multiomics Picture of Obesity in Young Adults.Biology · 2024Article
- Insulin Resistance in Pediatric Obesity: From Mechanisms to Treatment Strategies.Pediatric diabetes · 2024Review
- Review
- Maternal Gestational Diabetes Influences DNA Methylation in the Serotonin System in the Human Placenta.Life (Basel, Switzerland) · 2022Article
- Novel Subgroups of Type 2 Diabetes Display Different Epigenetic Patterns That Associate With Future Diabetic Complications.Diabetes care · 2022Article
- DNA methylation profile of genes involved in inflammation and autoimmunity correlates with vascular function in morbidly obese adults.Epigenetics · 2022Article
- Epigenetics as a Mechanism of Developmental Embodiment of Stress, Resilience, and Cardiometabolic Risk Across Generations of Latinx Immigrant Families.Frontiers in psychiatry · 2021Article
- Comparison of methylation capture sequencing and Infinium MethylationEPIC array in peripheral blood mononuclear cells.Epigenetics & chromatin · 2020Article
- Gestational Diabetes Mellitus and Developmental Programming.Annals of nutrition & metabolism · 2020Review
- Developmental Programming of Body Composition: Update on Evidence and Mechanisms.Current diabetes reports · 2019Review
- Family Factors Associated with Selected Childhood Nutrition Aspects in Central Poland.International journal of environmental research and public health · 2019Article
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Authors and funding
24 authors at 6 institutions in 3 countries.
Funding
Abstract
backgroundThe early life environment may influence susceptibility to obesity and metabolic disease in later life through epigenetic processes. SLC6A4 is an important mediator of serotonin bioavailability, and has a key role in energy balance. We tested the hypothesis that methylation of the SLC6A4 gene predicts adiposity across the life course.
methodsDNA methylation at 5 CpGs within the SLC6A4 gene identified from a previous methyl binding domain array was measured by pyrosequencing. We measured DNA methylation in umbilical cord (UC) from children in the Southampton Women's Survey cohort (n = 680), in peripheral blood from adolescents in the Western Australian Pregnancy Cohort Study (n = 812), and in adipose tissue from lean and obese adults from the UK BIOCLAIMS cohort (n = 81). Real-time PCR was performed to assess whether there were corresponding alterations in gene expression in the adipose tissue.
resultsLower UC methylation of CpG5 was associated with higher total fat mass at 4 years (p = 0.031), total fat mass at 6-7 years (p = 0.0001) and % fat mass at 6-7 years (p = 0.004). Lower UC methylation of CpG5 was also associated with higher triceps skinfold thickness at birth (p = 0.013), 6 months (p = 0.038), 12 months (p = 0.062), 2 years (p = 0.0003), 3 years (p = 0.00004) and 6-7 years (p = 0.013). Higher maternal pregnancy weight gain (p = 0.046) and lower parity (p = 0.029) were both associated with lower SLC6A4 CpG5 methylation. In adolescents, lower methylation of CpG5 in peripheral blood was associated with greater concurrent measures of adiposity including BMI (p ≤ 0.001), waist circumference (p = 0.011), subcutaneous fat (p ≤ 0.001) and subscapular, abdominal and suprailiac skinfold thicknesses (p = 0.002, p = 0.008, p = 0.004, respectively). In adipose tissue, methylation of both SLC6A4 CpG5 (p = 0.019) and expression of SLC6A4 (p = 0.008) was lower in obese compared with lean adults.
conclusionsThese data suggest that altered methylation of CpG loci within SLC6A4 may provide a robust marker of adiposity across the life course.
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