Evidence map›Paper›PMID 30622229›Full record

ArticleMolecules and cells2019

Loss of Primary Cilia Results in the Development of Cancer in the Murine Thyroid Gland.

Junguee Lee, Shinae Yi, Joon Young Chang, Jung Tae Kim, Hae Joung Sul, Ki Cheol Park, Xuguang Zhu, Sheue-Yann Cheng, Jukka Kero, Joon Kim and 1 more

Open access · greenAbstract read
In one paragraph

Article in Molecules and cells, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 24 citations in OpenAlex.

  1. Review
  2. Ciliary and Non-Ciliary Roles of IFT88 in Development and Diseases.International journal of molecular sciences · 2025
    Review
  3. Article
  4. International journal of molecular sciences · 2024
    Article
  5. Article
  6. Article
  7. The role of primary cilia in thyroid diseases.Frontiers in endocrinology · 2023
    Review
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Review
  18. CEP164 Deficiency Causes Hyperproliferation of Pancreatic Cancer Cells.Frontiers in cell and developmental biology · 2020
    Article
  19. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Junguee LeeDepartment of Pathology, Daejeon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Daejeon 34943, Korea.
Shinae YiResearch Center for Endocrine and Metabolic Diseases, Division of Endocrinology, Department of Internal Medicine, Chungnam National University School of Medicine, Daejeon 35015, Korea.
Joon Young ChangResearch Center for Endocrine and Metabolic Diseases, Division of Endocrinology, Department of Internal Medicine, Chungnam National University School of Medicine, Daejeon 35015, Korea.
Jung Tae KimResearch Center for Endocrine and Metabolic Diseases, Division of Endocrinology, Department of Internal Medicine, Chungnam National University School of Medicine, Daejeon 35015, Korea.
Hae Joung SulDepartment of Pathology, Daejeon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Daejeon 34943, Korea.
Ki Cheol ParkClinical Research Institute, Daejeon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Daejeon 34943, Korea.
Xuguang ZhuLaboratory of Molecular Biology, National Cancer Institute, MD 20892-4264, USA.
Sheue-Yann ChengLaboratory of Molecular Biology, National Cancer Institute, MD 20892-4264, USA.
Jukka KeroResearch Centre for Integrative Physiology and Pharmacology, Institute of Biomedicine, University of Turku, 20520 Turku, Finland.
Joon KimGraduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon 34040, Korea.
Minho ShongResearch Center for Endocrine and Metabolic Diseases, Division of Endocrinology, Department of Internal Medicine, Chungnam National University School of Medicine, Daejeon 35015, Korea.
University of Turku · FI

Funding

Thyroid Hormone Receptors in Health and DiseaseZIABC008752 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI CHENG, SHEUE-YANN · 2009 to 2025
$12.9M
6 · The paper itself

Abstract

Communications at the interface between the apical membrane of follicular cells and the follicular lumen are critical for the homeostasis of thyroid gland. Primary cilia at the apical membrane of thyroid follicular cells may sense follicular luminal environment and regulate follicular homeostasis, although their role

Indexed as

AnimalsCarcinogenesisCell Line, TumorCell ProliferationCiliaGene DeletionIntegrasesMaleMice, Inbred C57BLMice, TransgenicThyroid Epithelial CellsThyroid GlandThyroid NeoplasmsTumor Suppressor ProteinsCre recombinaseIntegrasesTg737Rpw protein, mouseTumor Suppressor Proteinsdefective ciliogenesisdilated and destroyed thyroid folliclemalignant transformationprimary cilia

Identifiers

PMID30622229
PMCPMC6399002
OpenAlexW2963488846

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.