Evidence map›Paper›PMID 30622225›Full record

ArticleMolecules and cells2019

Crystal Structure of Histidine Triad Nucleotide-Binding Protein from the Pathogenic Fungus

Ahjin Jung, Ji-Sook Yun, Shinae Kim, Sang Ryong Kim, Minsang Shin, Dong Hyung Cho, Kwang Shik Choi, Jeong Ho Chang

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules and cells, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 58% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. International journal of molecular sciences · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Ahjin JungDepartment of Biology Education, Kyungpook National University, Daegu 41566, Korea.
Ji-Sook YunDepartment of Biology Education, Kyungpook National University, Daegu 41566, Korea.
Shinae KimDepartment of Biology Education, Kyungpook National University, Daegu 41566, Korea.
Sang Ryong KimSchool of Life Sciences, BK21 Plus KNU Creative BioResearch Group, Kyungpook National University, Daegu 41566, Korea.
Minsang ShinDepartment of Microbiology, School of Medicine, Kyungpook National University, Daegu 41566, Korea.
Dong Hyung ChoSchool of Life Sciences, BK21 Plus KNU Creative BioResearch Group, Kyungpook National University, Daegu 41566, Korea.
Kwang Shik ChoiSchool of Life Sciences, BK21 Plus KNU Creative BioResearch Group, Kyungpook National University, Daegu 41566, Korea.
Jeong Ho ChangDepartment of Biology Education, Kyungpook National University, Daegu 41566, Korea.
Kyungpook National University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Histidine triad nucleotide-binding protein (HINT) is a member of the histidine triad (HIT) superfamily, which has hydrolase activity owing to a histidine triad motif. The HIT superfamily can be divided to five classes with functions in galactose metabolism, DNA repair, and tumor suppression. HINTs are highly conserved from archaea to humans and function as tumor suppressors, translation regulators, and neuropathy inhibitors. Although the structures of HINT proteins from various species have been reported, limited structural information is available for fungal species. Here, to elucidate the structural features and functional diversity of HINTs, we determined the crystal structure of HINT from the pathogenic fungus

Indexed as

Amino Acid SequenceCandida albicansCatalytic DomainCrystallography, X-RayFungal ProteinsHumansHydrolasesPhylogenyStructural Homology, ProteinFungal Proteinshistidine triad proteinHydrolasesCandida albicanscrystal structureHINThistidine triadHIT family

Identifiers

PMID30622225
PMCPMC6354057
OpenAlexW2912628307

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.