Evidence map›Paper›PMID 30622190›Full record

ArticlemBio2019

Corynebacterium pseudodiphtheriticum Exploits Staphylococcus aureus Virulence Components in a Novel Polymicrobial Defense Strategy.

Britney L Hardy, Seth W Dickey, Roger D Plaut, Daniel P Riggins, Scott Stibitz, Michael Otto, D Scott Merrell

Open access · goldAbstract read
In one paragraph

Article in mBio, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers.

0numbers the graph read from it
0cells of the map it votes in
66citing papers in PubMed
11.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

66 citing papers in PubMed, 105 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Journal of bacteriology · 2025
    Article
  5. Review
  6. [The role ofLin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2025
    Review
  7. Article
  8. AirwayInfection and immunity · 2025
    Article
  9. Rare constituents of the nasal microbiome contribute to the acute exacerbation of chronic rhinosinusitis.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2025
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Phenotypic Variation inAntibiotics (Basel, Switzerland) · 2024
    Review
  15. Metabolic capabilities are highly conserved among human nasal-associatedbioRxiv : the preprint server for biology · 2024
    Article
  16. The porcine skin microbiome exhibits broad fungal antagonism.Fungal genetics and biology : FG & B · 2024
    Article
  17. Antagonistic Effects ofMicroorganisms · 2024
    Article
  18. Review
  19. Review
  20. [Analysis of nasal flora composition in children with perennial allergic rhinitis].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2024
    Article

6 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Britney L HardyF. Edward Hébert School of Medicine, Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA.
Seth W DickeyPathogen Molecular Genetics Section, Laboratory of Bacteriology, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, Maryland, USA.
Roger D PlautDivision of Bacterial, Parasitic, and Allergenic Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, USA.
Daniel P RigginsDivision of Bacterial, Parasitic, and Allergenic Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, USA.
Scott StibitzDivision of Bacterial, Parasitic, and Allergenic Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, USA.
Michael OttoPathogen Molecular Genetics Section, Laboratory of Bacteriology, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, Maryland, USA.
D Scott MerrellF. Edward Hébert School of Medicine, Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA douglas.merrell@usuhs.edu.ORCID 0000-0001-7095-5177
Center for Biologics Evaluation and Research · USNational Institutes of Health · USUniformed Services University of the Health Sciences · US

Funding

Staphylococcal pathogenesisZIAAI000904 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI OTTO, MICHAEL · 2009 to 2025
$22.6M
Intramural NIH HHS ZIA AI000904
6 · The paper itself

Abstract

Commensal bacteria in the human nasal cavity are known to suppress opportunistic pathogen colonization by competing for limited space and nutrients. It has become increasingly apparent that some commensal bacteria also produce toxic compounds that directly inhibit or kill incoming competitors. Numerous studies suggest that microbial species-specific interactions can affect human nasal colonization by the opportunistic pathogen

Indexed as

AntibiosisBacterial ToxinsCorynebacteriumDNA Transposable ElementsGene Expression Regulation, BacterialHumansMicrobial ViabilityMicroscopy, Electron, TransmissionMutagenesis, InsertionalNasal CavityStaphylococcus aureusVirulence FactorsBacterial ToxinsDNA Transposable Elementsstaphylococcal delta toxinVirulence Factorscommensal bacteriaCorynebacteriumnasal microbiotapolymicrobial interactionsStaphylococcus aureus

Identifiers

PMID30622190
PMCPMC6325251
OpenAlexW2910733004

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.