ArticlemBio2019
Nonsteroidal Anti-inflammatory Drugs Alter the Microbiota and Exacerbate
Open access · goldAbstract read
In one paragraph
Article in mBio, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
5.1field-weighted citation impact, top 4% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
39 citing papers in PubMed, 55 citations in OpenAlex.
- Adjunctive Probiotics Alleviates Asthmatic Symptoms via Modulating the Gut Microbiome and Serum Metabolome.Microbiology spectrum · 2021Trial
- Gut microbiota in chronic inflammation: the interplay with lipid mediators.Gut microbes · 2026Review
- Stage-Dependent Embryolethality of Diclofenac Sodium: Quantitative Assessment of Dose-Time Interaction and Critical Windows of Susceptibility in the In Ovo Chicken Embryo Model.Veterinary sciences · 2026Article
- Hyperglycemia and systemic inflammation differentially shape immune dysregulation, tissue destruction, and microbiota in experimental periodontitis and peri-implantitis in diabetic mice.Frontiers in immunology · 2026Article
- Exploring the etiology of colitis: insights from gut microbiota research.Gut microbes · 2025Review
- Microbiota alterations are related to migraine food triggers and inflammatory markers in chronic migraine patients with medication overuse headache.The journal of headache and pain · 2024Article
- What We Know About the Actual Role of Traditional Probiotics in Health and Disease.Probiotics and antimicrobial proteins · 2024Review
- Clostridium difficile infection following colon subtotal resection in a patient with gallstones: A case report and review of literature.World journal of gastrointestinal surgery · 2024Article
- Developmental PFOS exposure alters lung inflammation and barrier integrity in juvenile mice.Toxicological sciences : an official journal of the Society of Toxicology · 2024Article
- Roles of the gut microbiota in human neurodevelopment and adult brain disorders.Frontiers in neuroscience · 2024Review
- Defining the environmental determinants of dysbiosis at scale with zebrafish.Current opinion in toxicology · 2023Article
- Nonsteroidal anti-inflammatory drugs sensitize epithelial cells toScience advances · 2023Article
- Microbiota and Mitochondrial Sex-Dependent Imbalance in Fibromyalgia: A Pilot Descriptive Study.Neurology international · 2023Article
- Review
- Advancing our understanding of the influence of drug induced changes in the gut microbiome on bone health.Frontiers in endocrinology · 2023Review
- Unveiling the interplay between NSAID-induced dysbiosis and autoimmune liver disease in children: insights into the hidden gateway to autism spectrum disorders. Evidence fromFrontiers in cellular neuroscience · 2023Article
- Comparison between Symptomatic and Asymptomatic Mice afterMicroorganisms · 2022Article
- Pain killers: the interplay between nonsteroidal anti-inflammatory drugs and Clostridioides difficile infection.Current opinion in microbiology · 2022Review
- Article
- Fecal Microbial Transplantation in Critically Ill Patients-Structured Review and Perspectives.Biomolecules · 2021Review
Corrections and comments
- Commented on by
- Commented on by
Authors and funding
15 authors at 3 institutions in 1 country.
Damian Maseda *Department of Pathology, Microbiology, and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.ORCID 0000-0003-0722-6881
Joseph P Zackular *Department of Pathology, Microbiology, and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.ORCID 0000-0002-3228-3055
Bruno TrindadeDepartment of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
Leslie KirkDepartment of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
Jennifer Lising RoxasSchool of Animal and Comparative Biomedical Sciences, University of Arizona, Tucson, Arizona, USA.
Lisa M RogersDepartment of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
Mary K WashingtonDepartment of Pathology, Microbiology, and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
Liping DuCenter for Quantitative Sciences, Department of Biostatistics, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
Tatsuki KoyamaCenter for Quantitative Sciences, Department of Biostatistics, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
V K ViswanathanSchool of Animal and Comparative Biomedical Sciences, University of Arizona, Tucson, Arizona, USA.
Gayatri VedantamSchool of Animal and Comparative Biomedical Sciences, University of Arizona, Tucson, Arizona, USA.
Patrick D SchlossDepartment of Microbiology and Immunology, University of Michigan, Ann Arbor, Michigan, USA.ORCID 0000-0002-6935-4275
Leslie J CroffordDepartment of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
Eric P SkaarDepartment of Pathology, Microbiology, and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
David M AronoffDepartment of Pathology, Microbiology, and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA d.aronoff@vanderbilt.edu.
Vanderbilt University · USUniversity of Arizona · USUniversity of Michigan · US
Funding
Translational Analysis CoreP30DK058404 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI RICHARD M. PEEK · 2002 to 2026
$29.9MTRAINING IN GASTROENTEROLOGYT32DK007673 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI RICHARD M. PEEK · 1992 to 2026
$8.4MRepurposing misoprostol to prevent recurrence of Clostridium difficile infectionU01TR002398 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI DOSTER, RYAN S, DUBBERKE, ERIK R · 2018 to 2019
$3.1MRepurposing misoprostol for Clostridium difficile colitis as identified by PheWASR21TR001723 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI ARONOFF, DAVID M · 2016 to 2017
$632kProstaglandins as protective mediators in Clostridium difficile infectionR21AI121796 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI ARONOFF, DAVID M · 2016 to 2017
$435kA safe, targeted, designer probiotic to prevent or treat C. difficile infectionR21AI121590 · NIAID · UNIVERSITY OF ARIZONA · PI VEDANTAM, GAYATRI · 2016 to 2017
$389kThe Impact of Vancomycin-Resistant Entercoccus on Clostridium difficile InfectionK22AI137220 · NIAID · CHILDREN'S HOSP OF PHILADELPHIA · PI ZACKULAR, JOSEPH PAUL · 2019 to 2020
$270kThe impact of dietary metals on the gut microbiome and Clostridium difficile infectionF32AI120553 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI ZACKULAR, JOSEPH PAUL · 2015 to 2017
$109kBLR&D Research Career Scientist Award ApplicationIK6BX003789 · VA · SOUTHERN ARIZONA VA HEALTH CARE SYSTEM · PI VEDANTAM, GAYATRI · 2017 to 2021
–BLRD VA IK6 BX003789NCATS NIH HHS R21 TR001723NCATS NIH HHS U01 TR002398NIAID NIH HHS F32 AI120553NIAID NIH HHS K22 AI137220NIAID NIH HHS R21 AI121590NIAID NIH HHS R21 AI121796NIDDK NIH HHS P30 DK058404NIDDK NIH HHS T32 DK007673
Abstract
PubMed holds no abstract for this paper.
Indexed as
AnimalsAnti-Inflammatory Agents, Non-SteroidalCD4-Positive T-LymphocytesClostridium InfectionsGastrointestinal MicrobiomeIndomethacinIntestinal MucosaMiceNeutrophilsProstaglandinsSurvival AnalysisAnti-Inflammatory Agents, Non-SteroidalIndomethacinProstaglandinsClostridium difficilecolitisgut inflammationimmune dysfunctionimmune responseinflammationintestinal immunityprostaglandin
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.