Evidence map›Paper›PMID 30622183›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2019

The RNA degradosome promotes tRNA quality control through clearance of hypomodified tRNA.

Satoshi Kimura, Matthew K Waldor

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers.

0numbers the graph read from it
0cells of the map it votes in
65citing papers in PubMed
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

65 citing papers in PubMed, 103 citations in OpenAlex.

  1. Compendium of RNA modifications for bacterial stress adaptation.Microbiology and molecular biology reviews : MMBR · 2026
    Review
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  12. Functions and therapeutic applications of pseudouridylation.Nature reviews. Molecular cell biology · 2025
    Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. RNA modifying enzymes shape tRNA biogenesis and function.The Journal of biological chemistry · 2024
    Review
  20. The modification landscape ofRNA (New York, N.Y.) · 2024
    Article

5 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Satoshi KimuraDivision of Infectious Diseases, Brigham and Women's Hospital, Boston, MA 02115; s.kimura.res@gmail.com mwaldor@research.bwh.harvard.edu.
Matthew K WaldorDivision of Infectious Diseases, Brigham and Women's Hospital, Boston, MA 02115; s.kimura.res@gmail.com mwaldor@research.bwh.harvard.edu.
Brigham and Women's Hospital · USHarvard University · US

Funding

Vibrio cholerae intestinal colonization and vaccine developmentR01AI042347 · NIAID · TUFTS UNIVERSITY BOSTON · PI WALDOR, MATTHEW K · 1998 to 2025
$7.3M
NIAID NIH HHS R01 AI042347
6 · The paper itself

Abstract

The factors and mechanisms that govern tRNA stability in bacteria are not well understood. Here, we investigated the influence of posttranscriptional modification of bacterial tRNAs (tRNA modification) on tRNA stability. We focused on ThiI-generated 4-thiouridine (s

Indexed as

ArchaeaBacteriaEndoribonucleasesKineticsMultienzyme ComplexesPeptide Elongation Factor TuPolyribonucleotide NucleotidyltransferaseQuality ControlRNA HelicasesRNA Processing, Post-TranscriptionalRNA, TransferThiouridineVibrio choleraedegradosomeEndoribonucleasesMultienzyme ComplexesPeptide Elongation Factor TuPolyribonucleotide NucleotidyltransferaseRNA HelicasesRNA, TransferThiouridineRNA degradosomestationary phasethiItRNA modificationVibrio cholerae

Identifiers

PMID30622183
PMCPMC6347707
OpenAlexW2909556667

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.