ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2019
PKMζ Inhibition Disrupts Reconsolidation and Erases Object Recognition Memory.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Co-activation of Selective Nicotinic Acetylcholine Receptor Subtypes Is Required for Neuroprotection against Alzheimer's Disease.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Rac1 Constrains Memory Consolidation.eNeuro · 2026Article
- Xenon gas as a potential treatment for opioid use disorder, alcohol use disorder, and related disorders.Medical gas research · 2025Review
- CaMKII modulates memory destabilization by regulating the interaction of theta and gamma oscillations.Frontiers in cellular neuroscience · 2025Article
- PKMζ drives spatial memory reconsolidation but not maintenance.Frontiers in synaptic neuroscience · 2025Article
- Novel object recognition in Octopus maya.Animal cognition · 2023Article
- Karim Nader and the unification of memory erasure: PKMζ inhibition and reconsolidation blockade.Brain research bulletin · 2023Review
- PyRAT: An Open-Source Python Library for Animal Behavior Analysis.Frontiers in neuroscience · 2022Article
- Reactivation-dependent amnesia for object recognition memory is contingent on hippocampal theta-gamma coupling during recall.Learning & memory (Cold Spring Harbor, N.Y.) · 2022Article
- Infusing zeta inhibitory peptide into the perirhinal cortex of rats abolishes long-term object recognition memory without affecting novel object location recognition.Frontiers in behavioral neuroscience · 2022Article
- On the effect of hippocampal c-Jun N-terminal kinase inhibition on object recognition memory.Frontiers in behavioral neuroscience · 2022Article
- Dopamine controls whether new declarative information updates reactivated memories through reconsolidation.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Modeling suggests combined-drug treatments for disorders impairing synaptic plasticity via shared signaling pathways.Journal of computational neuroscience · 2021Article
- Injection of Anti-proBDNF Attenuates Hippocampal-Dependent Learning and Memory Dysfunction in Mice With Sepsis-Associated Encephalopathy.Frontiers in neuroscience · 2021Article
- mTOR inhibition impairs extinction memory reconsolidation.Learning & memory (Cold Spring Harbor, N.Y.) · 2021Article
- Role of prelimbic cortex PKC and PKMζ in fear memory reconsolidation and persistence following reactivation.Scientific reports · 2020Article
- Recognition memory reconsolidation requires hippocampal Zif268.Scientific reports · 2019Article
- How can memories last for days, years, or a lifetime? Proposed mechanisms for maintaining synaptic potentiation and memory.Learning & memory (Cold Spring Harbor, N.Y.) · 2019Review
- On the Involvement of BDNF Signaling in Memory Reconsolidation.Frontiers in cellular neuroscience · 2019Review
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Object recognition memory (ORM) confers the ability to discriminate the familiarity of previously encountered items. Reconsolidation is the process by which reactivated memories become labile and susceptible to modifications. The hippocampus is specifically engaged in reconsolidation to integrate new information into the original ORM through a mechanism involving activation of brain-derived neurotrophic factor (BDNF) signaling and induction of LTP. It is known that BDNF can control LTP maintenance through protein kinase Mζ (PKMζ), an atypical protein kinase C isoform that is thought to sustain memory storage by modulating glutamatergic neurotransmission. However, the potential involvement of PKMζ in ORM reconsolidation has never been studied. Using a novel ORM task combined with pharmacological, biochemical, and electrophysiological tools, we found that hippocampal PKMζ is essential to update ORM through reconsolidation, but not to maintain the inactive recognition memory trace stored over time, in adult male Wistar rats. Our results also indicate that hippocampal PKMζ acts downstream of BDNF and controls AMPAR synaptic insertion to elicit reconsolidation and suggest that blocking PKMζ activity during this process deletes active ORM.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.