Evidence map›Paper›PMID 30622162›Full record

ArticleJournal of lipid research2019

Genetic control of the mouse HDL proteome defines HDL traits, function, and heterogeneity.

Nathalie Pamir, Calvin Pan, Deanna L Plubell, Patrick M Hutchins, Chongren Tang, Jake Wimberger, Angela Irwin, Thomas Q de Aguiar Vallim, Jay W Heinecke, Aldons J Lusis

Open access · hybridAbstract read
In one paragraph

Article in Journal of lipid research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 28 citations in OpenAlex.

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  10. Pig and Mouse Models of Hyperlipidemia and Atherosclerosis.Methods in molecular biology (Clifton, N.J.) · 2022
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  16. MicroRNA-144 Silencing Protects Against Atherosclerosis in Male, but Not Female Mice.Arteriosclerosis, thrombosis, and vascular biology · 2020
    Article
  17. Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Nathalie PamirDepartment of Medicine, Knight Cardiovascular Institute, Oregon Health and Science University, Portland, OR pamir@ohsu.edu.ORCID 0000-0002-2074-888X
Calvin PanDepartments of Genetics University of California at Los Angeles, Los Angeles, CA.
Deanna L PlubellDepartment of Medicine, Knight Cardiovascular Institute, Oregon Health and Science University, Portland, OR.
Patrick M HutchinsDepartment of Medicine University of Washington, Seattle, WA.
Chongren TangDepartment of Medicine University of Washington, Seattle, WA.
Jake WimbergerDepartment of Medicine University of Washington, Seattle, WA.
Angela IrwinDepartment of Medicine University of Washington, Seattle, WA.
Thomas Q de Aguiar VallimBiological Chemistry, University of California at Los Angeles, Los Angeles, CA.
Jay W HeineckeDepartment of Medicine University of Washington, Seattle, WA.
Aldons J LusisDepartments of Genetics University of California at Los Angeles, Los Angeles, CA.
University of Washington · USUniversity of California, Los Angeles · USOregon Health & Science University · US

Funding

ULTRASTRUCTURE OF THE INTIMA IN EARLY LESION FORMATIONP01HL030568 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI TONTONOZ, PETER J · 1985 to 2019
$55.2M
Systems genomics of metabolic syndrome traitsP01HL028481 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DAVIS, RICHARD C · 1985 to 2019
$50.2M
Vector and Transgenic Mouse CoreP30DK017047 · NIDDK · UNIVERSITY OF WASHINGTON · PI Sakeneh Zraika · 1986 to 2026
$41.4M
Structural Determinants Of Ceruloplasmin Inflammatory ActivityP01HL076491 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI HAZEN, STANLEY L · 2004 to 2019
$27.3M
Role of Serum Amyloid A in Diabetic Vascular DiseaseP01HL092969 · NHLBI · UNIVERSITY OF WASHINGTON · PI GOLDBERG, IRA J · 2008 to 2019
$23.5M
CARDIOVASCULAR RESEARCH TRAINING PROGRAMT32HL007828 · NHLBI · UNIVERSITY OF WASHINGTON · PI Francis Kim, Farid Moussavi-Harami · 1997 to 2026
$10.2M
Identification of the role of HDL function in human cardiovascular disease through proteomics and geneticsR01HL136373 · NHLBI · OREGON HEALTH & SCIENCE UNIVERSITY · PI PAMIR, NATHALIE · 2018 to 2022
$2.4M
Regulation of ABCA1 functions by JAK2/STAT3 pathwayR01HL121214 · NHLBI · UNIVERSITY OF WASHINGTON · PI TANG, CHONGREN · 2014 to 2018
$2.2M
Quantitative Assessment of HDL FunctionR01HL112625 · NHLBI · UNIVERSITY OF WASHINGTON · PI HEINECKE, JAY W · 2012 to 2016
$2.1M
Transcriptional control of microRNAs in lipid metabolism and atherosclerosisR01HL122677 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI VALLIM, THOMAS A · 2016 to 2020
$1.9M
Cardioprotective Mechanisms of HDLR01HL108897 · NHLBI · UNIVERSITY OF WASHINGTON · PI HEINECKE, JAY W · 2012 to 2015
$1.7M
APOC3, HDL Function and Cardiovascular Complications of T1DMDP3DK108209 · NIDDK · UNIVERSITY OF WASHINGTON · PI BORNFELDT, KARIN E., HEINECKE, JAY W · 2015 to 2015
$1.6M
NHLBI NIH HHS P01 HL028481NHLBI NIH HHS P01 HL030568NHLBI NIH HHS P01 HL076491NHLBI NIH HHS P01 HL092969NHLBI NIH HHS R01 HL108897NHLBI NIH HHS R01 HL112625NHLBI NIH HHS R01 HL121214NHLBI NIH HHS R01 HL122677NHLBI NIH HHS R01 HL136373NHLBI NIH HHS T32 HL007828NIDDK NIH HHS DP3 DK108209NIDDK NIH HHS P30 DK017047
6 · The paper itself

Abstract

HDLs are nanoparticles with more than 80 associated proteins, phospholipids, cholesterol, and cholesteryl esters. The potential inverse relation of HDL to coronary artery disease (CAD) and the effects of HDL on myriad other inflammatory conditions warrant a better understanding of the genetic basis of the HDL proteome. We conducted a comprehensive genetic analysis of the regulation of the proteome of HDL isolated from a panel of 100 diverse inbred strains of mice (the hybrid mouse diversity panel) and examined protein composition and efflux capacity to identify novel factors that affect the HDL proteome. Genetic analysis revealed widely varied HDL protein levels across the strains. Some of this variation was explained by local

Indexed as

AnimalsCell LineCholesterol, HDLMiceProteomeQuantitative Trait LociCholesterol, HDLProteomehigh density lipoproteinsingle nucleotide polymorphismsterol efflux

Identifiers

PMID30622162
PMCPMC6399512
OpenAlexW2910396588

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.