Evidence map›Paper›PMID 30622155›Full record

ArticleJournal of the American Society of Nephrology : JASN2019

Activation and Proliferation of PD-1

Mohanraj Sadasivam, Sanjeev Noel, Sul A Lee, Jing Gong, Mohamad E Allaf, Phillip Pierorazio, Hamid Rabb, Abdel Rahim A Hamad

Open access · bronzeAbstract read
In one paragraph

Article in Journal of the American Society of Nephrology : JASN, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 36 citations in OpenAlex.

  1. Article
  2. IL-17ACR open rheumatology · 2025
    Article
  3. Article
  4. CD3Frontiers in immunology · 2025
    Review
  5. Review
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. T-cell receptor αβImmunology and cell biology · 2023
    Article
  16. Article
  17. Review
  18. Review
  19. Article
  20. Role of T cells in ischemic acute kidney injury and repair.The Korean journal of internal medicine · 2022
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Mohanraj SadasivamDepartment of Pathology.
Sanjeev NoelDivision of Nephrology, and.
Sul A LeeDivision of Nephrology, and.
Jing GongDivision of Nephrology, and.
Mohamad E AllafDepartment of Urology, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Phillip PierorazioDivision of Nephrology, and.
Hamid RabbDivision of Nephrology, and hrabb1@jhmi.edu.
Abdel Rahim A HamadDepartment of Pathology.
Pediatric Nephrology of Alabama · USJohns Hopkins University · US

Funding

Acute Kidney Injury and Double Negative T CellsR01DK104662 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI HAMAD, ABDEL RAHIM, RABB, HAMID · 2015 to 2023
$3.8M
Targeting T lymphocyte Keap1 for acute kidney injuryR01DK111209 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI RABB, HAMID · 2016 to 2019
$1.8M
NIDDK NIH HHS R01 DK104662NIDDK NIH HHS R01 DK111209
6 · The paper itself

Abstract

backgroundCD4

methodsWe used knockout mice, functional assays, and an established ischemic AKI model to investigate the role of various MHC class I and II molecules in regulating kidney DN T cells. We also studied human nephrectomy samples.

resultsDeficiency of

conclusionsDN T cells, a unique population of kidney T cells, depend on nonclassical

Indexed as

Acute Kidney InjuryAnimalsAntigens, SurfaceCells, CulturedDisease Models, AnimalHistocompatibility Antigens Class IIInterleukin-2Lymphocyte ActivationMiceMice, Inbred C57BLMice, KnockoutProgrammed Cell Death 1 ReceptorRandom AllocationReference ValuesSensitivity and SpecificityT-Lymphocyte SubsetsAntigens, SurfaceHistocompatibility Antigens Class IIInterleukin-2Programmed Cell Death 1 Receptorimmunologyischemia-reperfusionT cells

Identifiers

PMID30622155
PMCPMC6362627
OpenAlexW2909962432

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.