Evidence map›Paper›PMID 30622121›Full record

ArticleBlood2019

A topological view of human CD34

David J H F Knapp, Colin A Hammond, Fangwu Wang, Nima Aghaeepour, Paul H Miller, Philip A Beer, Davide Pellacani, Michael VanInsberghe, Carl Hansen, Sean C Bendall and 2 more

Abstract read
In one paragraph

Article in Blood, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Modeling the Hematopoietic Landscape.Frontiers in cell and developmental biology · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

David J H F KnappTerry Fox Laboratory, British Columbia Cancer Agency, Vancouver, BC, Canada.ORCID 0000-0002-2161-9959
Colin A HammondTerry Fox Laboratory, British Columbia Cancer Agency, Vancouver, BC, Canada.
Fangwu WangTerry Fox Laboratory, British Columbia Cancer Agency, Vancouver, BC, Canada.
Nima AghaeepourBaxter Laboratory for Stem Cell Biology, Department of Microbiology and Immunology, Stanford University, Palo Alto, CA.
Paul H MillerTerry Fox Laboratory, British Columbia Cancer Agency, Vancouver, BC, Canada.ORCID 0000-0002-4216-2716
Philip A BeerTerry Fox Laboratory, British Columbia Cancer Agency, Vancouver, BC, Canada.
Davide PellacaniTerry Fox Laboratory, British Columbia Cancer Agency, Vancouver, BC, Canada.ORCID 0000-0002-0522-8229
Michael VanInsbergheMichael Smith Laboratories and.ORCID 0000-0001-8418-4393
Carl HansenMichael Smith Laboratories and.
Sean C BendallDepartment of Pathology, Stanford University, Palo Alto, CA.ORCID 0000-0003-1341-2453
Garry P NolanBaxter Laboratory for Stem Cell Biology, Department of Microbiology and Immunology, Stanford University, Palo Alto, CA.
Connie J EavesTerry Fox Laboratory, British Columbia Cancer Agency, Vancouver, BC, Canada.

Funding

Using a tonsil organoid system to probe conditions for the induction of protective antibody and T cell responses to influenza.U19AI057229 · NIAID · STANFORD UNIVERSITY · PI Mark Morris Davis · 2003 to 2026
$88.5M
CIHR CIHR-262119NIAID NIH HHS U19 AI057229
6 · The paper itself

Abstract

Recent advances in single-cell molecular analytical methods and clonal growth assays are enabling more refined models of human hematopoietic lineage restriction processes to be conceptualized. Here, we report the results of integrating single-cell proteome measurements with clonally determined lymphoid, neutrophilic/monocytic, and/or erythroid progeny outputs from >1000 index-sorted CD34

Indexed as

Cell LineageAntigens, CD34Cell DifferentiationCells, CulturedFetal BloodHematopoietic Stem CellsHumansProteomeSingle-Cell AnalysisAntigens, CD34Proteome

Identifiers

PMID30622121
PMCPMC6396178

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.