Evidence map›Paper›PMID 30622047›Full record

Trial reportPsychiatry research. Neuroimaging2019

Self-referential processing during observation of a speech performance task in social anxiety disorder from pre- to post-treatment: Evidence of disrupted neural activation.

Lily A Brown, Katherine S Young, Philippe R Goldin, Jared B Torre, Lisa J Burklund, Carolyn D Davies, Andrea N Niles, Matthew D Lieberman, Darby E Saxbe, Michelle G Craske

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Psychiatry research. Neuroimaging, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Trial
  5. Review
  6. Review
  7. Neural circuit basis of pathological anxiety.Nature reviews. Neuroscience · 2025
    Review
  8. Neurocircuitry of treatment in anxiety disorders.Biomarkers in neuropsychiatry · 2022
    Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Lily A BrownDepartment of Psychology, University of California, Los Angeles, 405 Hilgard Avenue, Los Angeles, CA, 90095, USA; Department of Psychiatry, University of Pennsylvania, 3535 Market Street Suite 600 N Philadelphia, PA 19104, USA. Electronic address: lilybr@upenn.edu.
Katherine S YoungDepartment of Psychology, University of California, Los Angeles, 405 Hilgard Avenue, Los Angeles, CA, 90095, USA; Social, Genetic and Development Psychiatry (SGDP) Centre, Institute of Psychology, Psychiatry and Neuroscience, King's College London, UK. Electronic address: katherine.s.young@kcl.ac.uk.
Philippe R GoldinBetty Irene Moore School of Nursing, University of California, Davis, 4610 X Street Suite 4202, Sacramento, CA 95817, USA. Electronic address: pgoldin@ucdavis.edu.
Jared B TorreDepartment of Psychology, University of California, Los Angeles, 405 Hilgard Avenue, Los Angeles, CA, 90095, USA. Electronic address: jtorre@psych.ucla.edu.
Lisa J BurklundDepartment of Psychology, University of California, Los Angeles, 405 Hilgard Avenue, Los Angeles, CA, 90095, USA; NeuroGen Technologies, Inc., P.O. Box 775 Burbank, CA 91505, USA. Electronic address: burklund@ucla.edu.
Carolyn D DaviesDepartment of Psychology, University of California, Los Angeles, 405 Hilgard Avenue, Los Angeles, CA, 90095, USA. Electronic address: cdavies@psych.ucla.edu.
Andrea N NilesDepartment of Psychology, University of California, Los Angeles, 405 Hilgard Avenue, Los Angeles, CA, 90095, USA. Electronic address: aniles@ucla.edu.
Matthew D LiebermanDepartment of Psychology, University of California, Los Angeles, 405 Hilgard Avenue, Los Angeles, CA, 90095, USA. Electronic address: lieber@ucla.edu.
Darby E SaxbeDepartment of Psychology, University of Southern California, 3620 South McClintock Avenue, Los Angeles, CA 90089, USA. Electronic address: dsaxbe@usc.edu.
Michelle G CraskeDepartment of Psychology, University of California, Los Angeles, 405 Hilgard Avenue, Los Angeles, CA, 90095, USA. Electronic address: craske@psych.ucla.edu.

Funding

Neural mediators of behavior therapy for anxietyR21MH081299 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CRASKE, MICHELLE G · 2008 to 2009
$402k
NIMH NIH HHS R21 MH081299
6 · The paper itself

Abstract

Self-referential processing is critical to understanding social anxiety disorder (SAD). This study examined neural differences in self-referential processing in healthy controls (HC) and participants with SAD at pre- and post-treatment. Participants (n = 64) underwent fMRI scanning while viewing a video of themselves ("Self") or another person ("Other"). SAD participants were randomized to cognitive behavior therapy (CBT), acceptance and commitment therapy (ACT), or waitlist, and were re-scanned at post-treatment. In SAD vs. HC, the fusiform face area (FFA) showed significantly more activation during Self vs. Other, and greater SAD severity was associated with significantly more activation during Self vs. Other in the right FFA and the left extrastriate body area (EBA). Greater reduction in SAD severity was associated with stronger connectivity between the amygdala and FFA during Self vs. Other at post-treatment, whereas the strength of connectivity during Self and Other was comparable at post-treatment for those with less SAD reduction. Thus, there were significant differences in activation and functional connectivity of brain regions implicated in self-referential processing in SAD. Change in connectivity between the amygdala and FFA were observed as a function of change in SAD severity, suggesting that improvements in SAD severity may correct this altered functional connectivity.

Indexed as

Magnetic Resonance ImagingSelf-AssessmentAcceptance and Commitment TherapyAdultAmygdalaBrainCognitive Behavioral TherapyFemaleHumansMalePhobia, SocialSpeechTreatment OutcomeYoung AdultAcceptance and commitment therapyCognitive behavior therapySelf-referential processingSocial anxiety disorder

Identifiers

PMID30622047
PMCPMC6415528

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.