Evidence map›Paper›PMID 30621912›Full record

ReviewTrends in neurosciences2019

Schizophrenia, Dopamine and the Striatum: From Biology to Symptoms.

Robert A McCutcheon, Anissa Abi-Dargham, Oliver D Howes

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Trends in neurosciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 414 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
414citing papers in PubMed, 10 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

414 citing papers in PubMed, 10 syntheses or guidelines pooled it.

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  15. Article
  16. Article
  17. A frontotemporal dementia-like phenotype in schizophrenia: links to striatal dopamine and iron accumulation.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Observational
  18. Article
  19. Review
  20. Noninvasive Mapping of Striosome-Matrix Imbalance in Early Psychosis.Biological psychiatry global open science · 2026
    Article

354 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Robert A McCutcheonDepartment of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, De Crespigny Park, London, SE5 8AF, UK; MRC London Institute of Medical Sciences, Hammersmith Hospital, London, W12 0NN, UK; Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, W12 0NN, UK; South London and Maudsley NHS Foundation Trust, London, SE5 8AF, UK.
Anissa Abi-DarghamDepartment of Psychiatry, School of Medicine, Stony Brook University, New York, USA.
Oliver D HowesDepartment of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, De Crespigny Park, London, SE5 8AF, UK; MRC London Institute of Medical Sciences, Hammersmith Hospital, London, W12 0NN, UK; Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, W12 0NN, UK; South London and Maudsley NHS Foundation Trust, London, SE5 8AF, UK. Electronic address: oliver.howes@kcl.ac.uk.

Funding

Department of HealthMedical Research Council MC-A656-5QD30Medical Research Council MC_U120097115Wellcome Trust 094849Wellcome Trust 200102
6 · The paper itself

Abstract

The mesolimbic hypothesis has been a central dogma of schizophrenia for decades, positing that aberrant functioning of midbrain dopamine projections to limbic regions causes psychotic symptoms. Recently, however, advances in neuroimaging techniques have led to the unanticipated finding that dopaminergic dysfunction in schizophrenia is greatest within nigrostriatal pathways, implicating the dorsal striatum in the pathophysiology and calling into question the mesolimbic theory. At the same time our knowledge of striatal anatomy and function has progressed, suggesting new mechanisms via which striatal dysfunction may contribute to the symptoms of schizophrenia. This Review draws together these developments, to explore what they mean for our understanding of the pathophysiology, clinical manifestations, and treatment of the disorder.

Indexed as

NeuroimagingCognitionCorpus StriatumDopamineHumansPsychotic DisordersSchizophreniaDopamineantipsychoticmagnetic resonance imagingneuroimagingnigrostriatalpositron emission tomographypsychosis

Identifiers

PMID30621912
PMCPMC6401206

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.