Evidence map›Paper›PMID 30621856›Full record

ReviewAlcohol (Fayetteville, N.Y.)2019

Optogenetic investigation of neural mechanisms for alcohol-use disorder.

Barbara Juarez, Yutong Liu, Lu Zhang, Ming-Hu Han

Open access · greenAbstract readReview
In one paragraph

Review in Alcohol (Fayetteville, N.Y.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.5field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
  2. Article
  3. Synaptic Effects Induced by Alcohol.Current topics in behavioral neurosciences · 2025
    Review
  4. Review
  5. Review
  6. Article
  7. New era of optogenetics: from the central to peripheral nervous system.Critical reviews in biochemistry and molecular biology · 2020
    Review
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Barbara JuarezDepartment of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, United States; Department of Pharmacology, University of Washington, Seattle, WA, United States.
Yutong LiuDepartment of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, United States; Key Laboratory of Functional Proteomics of Guangdong Province, Department of Pathophysiology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong, China.
Lu ZhangKey Laboratory of Functional Proteomics of Guangdong Province, Department of Pathophysiology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong, China.
Ming-Hu HanDepartment of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, United States; Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States. Electronic address: ming-hu.han@mssm.edu.
Southern Medical University · CNAllen Institute for Brain Science · USUniversity of Washington · US

Funding

TRAINING IN THE MOLECULAR PHARMACOLOGY OF ABUSED DRUGST32DA007278 · NIDA · UNIVERSITY OF WASHINGTON · PI Susan Marie Ferguson, Paul E. M. Phillips · 1993 to 2026
$9.8M
Rapid and Long-Lasting Antidepressant Action by Targeting Midbrain HCN ChannelsR01MH120637 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI RUSSO, SCOTT JAMES · 2019 to 2022
$1.8M
Neurophysiological Mechanisms of Variable Alcohol Drinking BehaviorsR01AA022445 · NIAAA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI HAN, MING-HU · 2014 to 2018
$1.7M
Rapid and Long-Lasting Antidepressant Action by Targeting Midbrain HCN ChannelsR56MH115409 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI HAN, MING-HU · 2018 to 2018
$587k
Optogenetic dissection of neural circuits underlying alcohol drinking behaviorsF31AA022862 · NIAAA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI JUAREZ, BARBARA · 2014 to 2016
$103k
NIAAA NIH HHS F31 AA022862NIAAA NIH HHS R01 AA022445NIDA NIH HHS T32 DA007278NIMH NIH HHS R01 MH120637NIMH NIH HHS R56 MH115409
6 · The paper itself

Abstract

Optogenetic techniques have been widely used in the study of neuropsychiatric diseases such as anxiety, depression, and drug addiction. Cell-type specific targeting of optogenetic tools to neurons has contributed to a tremendous understanding of the function of neural circuits for future treatment of neuropsychiatric disorders. Though optogenetics has been widely used in many research areas, the use of optogenetic tools to uncover and elucidate neural circuit mechanisms of alcohol's actions in the brain are still developing. Here in this review article, we will provide a basic introduction to optogenetics and discuss how these optogenetic experimental approaches can be used in alcohol studies to reveal neural circuit mechanisms of alcohol's actions in regions implicated in the development of alcohol addiction.

Indexed as

AlcoholismAmygdalaAnimalsBrainHabenulaHumansNucleus AccumbensOptogeneticsVentral Tegmental AreaAlcohol-use disorderNeural circuitOptogenetics

Identifiers

PMID30621856
PMCPMC7581464
OpenAlexW2808733657

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.