Evidence map›Paper›PMID 30621831›Full record

Trial reportJournal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine2019

Cognitive Behavioral Therapy for Insomnia Reduces Depression in Cancer Survivors.

Anita R Peoples, Sheila N Garland, Wilfred R Pigeon, Michael L Perlis, Julie Rya Wolf, Kathi L Heffner, Karen M Mustian, Charles E Heckler, Luke J Peppone, Charles S Kamen and 2 more

Registry-linked trialAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01091974 (Cognitive Behavioral Therapy +/- Armodafinil for Insomnia and Fatigue Following Chemotherapy), which is not on this map. Cited by 32 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01091974 phase2completednot on this map

Cognitive Behavioral Therapy +/- Armodafinil for Insomnia and Fatigue Following Chemotherapy

TypeinterventionalSponsorUniversity of RochesterRan2008 to 2013Enrolled138ConditionsInsomnia, Fatigue, Breast CancerArmsarmodafinil, Placebo Comparator, CBT-I
3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Trial
  5. Trial
  6. Trial
  7. Trial
  8. Article
  9. Review
  10. Insomnia associated with patient-reported outcomes in head and neck cancer survivors.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. The Effect of a Supportive Educational Intervention Through Virtual Social Networks on Sleep Quality and Insomnia of Patients with Cancer.Journal of cancer education : the official journal of the American Association for Cancer Education · 2023
    Article
  17. Article
  18. Article
  19. Tailored Psychological Interventions to Manage Body Image: An Opinion Study on Breast Cancer Survivors.International journal of environmental research and public health · 2023
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Anita R PeoplesClinical and Translational Science Institute, University of Rochester Medical Center, Rochester, New York.
Sheila N GarlandDepartments of Psychology and Oncology, Memorial University, Newfoundland, Canada.
Wilfred R PigeonDepartments of Psychiatry and Public Health Sciences, University of Rochester Medical Center, Rochester, New York.
Michael L PerlisDepartment of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania.
Julie Rya WolfDepartments of Dermatology and Radiation Oncology, University of Rochester Medical Center, Rochester, New York.
Kathi L HeffnerSchool of Nursing and Department of Psychiatry, University of Rochester Medical Center, Rochester, New York.
Karen M MustianDepartment of Surgery, University of Rochester Medical Center, Rochester, New York.
Charles E HecklerDepartment of Surgery, University of Rochester Medical Center, Rochester, New York.
Luke J PepponeDepartment of Surgery, University of Rochester Medical Center, Rochester, New York.
Charles S KamenDepartment of Surgery, University of Rochester Medical Center, Rochester, New York.
Gary R MorrowDepartment of Surgery, University of Rochester Medical Center, Rochester, New York.
Joseph A RoscoeDepartment of Surgery, University of Rochester Medical Center, Rochester, New York.

Funding

URCC NCORP Research BaseUG1CA189961 · NCI · UNIVERSITY OF ROCHESTER · PI Michelle C Janelsins, KAREN M. MUSTIAN · 2014 to 2026
$67.7M
Cancer Control Research Training Curriculum (R25T)R25CA102618 · NCI · UNIVERSITY OF ROCHESTER · PI JANELSINS, MICHELLE C, MORROW, GARY R · 2004 to 2018
$6.7M
NRSA Training CoreTL1TR002000 · NCATS · UNIVERSITY OF ROCHESTER · PI THAKAR, JUILEE, VAN WIJNGAARDEN, EDWIN · 2016 to 2024
$4.1M
CBT +/- Modafinil for Insomnia and Fatigue following ChemotherapyR01CA126968 · NCI · UNIVERSITY OF ROCHESTER · PI ROSCOE, JOSEPH A · 2008 to 2012
$2.4M
Behavioral Sleep Medicine: Training in Sleep and AgingK24AG055602 · NIA · UNIVERSITY OF PENNSYLVANIA · PI Michael Lloyd Perlis · 2017 to 2026
$1.6M
NCATS NIH HHS TL1 TR002000NCI NIH HHS R01 CA126968NCI NIH HHS R25 CA102618NCI NIH HHS UG1 CA189961NIA NIH HHS K24 AG055602
6 · The paper itself

Abstract

STUDY

objectivesThe current archival analyses examine the direct and indirect effects of cognitive behavioral therapy for insomnia (CBT-I) on depression in cancer survivors.

methodsWe report on 67 cancer survivors from a 2 × 2 randomized controlled trial of CBT-I and armodafinil for insomnia, after collapsing across the noneffective study medication conditions (armodafinil/placebo) to create CBT-I (yes/no). Depression and insomnia were assessed before, during the 7-week CBT-I intervention, at postintervention, and 3 months later by the Patient Health Questionnaire and the Insomnia Severity Index, respectively.

resultsMean depression at baseline for all participants was 6.44 (standard error = 0.41, range 0-15). Paired

conclusionsOur findings provide preliminary support that in cancer survivors, CBT-I reduces depression via improvement in insomnia. Further, this reduction in depression remained stable 3 months after completing CBT-I. This suggests that a CBT-I intervention has a meaningful effect on depression. CLINICAL

trial registrationRegistry: ClinicalTrials.gov; Title: Cognitive Behavioral Therapy +/- Armodafinil for Insomnia and Fatigue Following Chemotherapy; Identifier: NCT01091974; URL: https://clinicaltrials.gov/ct2/show/record/NCT01091974.

Indexed as

AdultAgedCancer SurvivorsCognitive Behavioral TherapyDepressive DisorderFemaleHumansMaleMiddle AgedSleep Initiation and Maintenance DisordersTreatment Outcomecancercancer survivorsCBT-Idepressioninsomniasleep deficiencysleep-wake disturbances

Identifiers

PMID30621831
PMCPMC6329536

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.