Evidence map›Paper›PMID 30621829›Full record

ArticleJournal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine2019

Early Postoperative Actigraphy Poorly Predicts Hypoactive Delirium.

Hannah R Maybrier, C Rya King, Amanda E Crawford, Angela M Mickle, Daniel A Emmert, Troy S Wildes, Michael S Avidan, Ben Julian A Palanca, ENGAGES Study Investigators

Registry-linked trialOpen access · bronzeAbstract read
In one paragraph

Article in Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02241655 (Electroencephalography Guidance of Anesthesia to Alleviate Geriatric Syndromes), which is not on this map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.3field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02241655 naunknown statusnot on this map

Electroencephalography Guidance of Anesthesia to Alleviate Geriatric Syndromes (ENGAGES) Study

TypeinterventionalSponsorWashington University School of MedicineRan2015 to 2020Enrolled1,400ConditionsDeliriumArmsa pragmatic EEG-guided anesthetic protocol
3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 9 citations in OpenAlex.

  1. Trial
  2. Predicting and Early Detection of Delirium through Motion Patterns: A Narrative Review.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2026
    Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Data Handling for E-Mental Health Professionals.Indian journal of psychological medicine · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Hannah R MaybrierDepartment of Anesthesiology, Washington University School of Medicine in St. Louis, St. Louis, Missouri.
C Rya KingDepartment of Anesthesiology, Washington University School of Medicine in St. Louis, St. Louis, Missouri.
Amanda E CrawfordDepartment of Anesthesiology, Washington University School of Medicine in St. Louis, St. Louis, Missouri.
Angela M MickleDepartment of Anesthesiology, Washington University School of Medicine in St. Louis, St. Louis, Missouri.
Daniel A EmmertDepartment of Anesthesiology, Washington University School of Medicine in St. Louis, St. Louis, Missouri.
Troy S WildesDepartment of Anesthesiology, Washington University School of Medicine in St. Louis, St. Louis, Missouri.
Michael S AvidanDepartment of Anesthesiology, Washington University School of Medicine in St. Louis, St. Louis, Missouri.
Ben Julian A PalancaDepartment of Anesthesiology, Washington University School of Medicine in St. Louis, St. Louis, Missouri.
ENGAGES Study Investigators
Washington University in St. Louis · US

Funding

WU INSTITUTE OF CLINICAL AND TRANSLATIONAL SCIENCESUL1TR002345 · NCATS · WASHINGTON UNIVERSITY · PI William G. Powderly · 2017 to 2026
$97.8M
Washington University Institute of Clinical and Translational SciencesUL1TR000448 · NCATS · WASHINGTON UNIVERSITY · PI EVANOFF, BRADLEY A · 2012 to 2016
$41.4M
Washington University Institute of Clinical and Translational Sciences (KL2) KL2TR002346 · NCATS · WASHINGTON UNIVERSITY · PI Dominic N Reeds · 2017 to 2026
$14.0M
Washington University Institute of Clinical and Translational SciencesKL2TR000450 · NCATS · WASHINGTON UNIVERSITY · PI EVANOFF, BRADLEY A · 2012 to 2016
$8.8M
TRAINING PROGRAM IN ANESTHESIOLOGY RESEARCHT32GM108539 · NIGMS · WASHINGTON UNIVERSITY · PI Aaron J Norris · 2014 to 2026
$4.9M
ELECTROENCEPHALOGRAPH GUIDANCE OF ANESTHESIA TO ALLEVIATE GERIATRIC SYNDROMES (ENGAGES)UH3AG050312 · NIA · WASHINGTON UNIVERSITY · PI AVIDAN, MICHAEL SIMON · 2015 to 2018
$2.4M
POSTOPERATIVE DELIRIUM AND ELECTROENCEPHALOGRAPHIC MEASURES OF SLEEP AND WAKEFULNESSR01AG057901 · NIA · WASHINGTON UNIVERSITY · PI PALANCA, BEN JULIAN · 2018 to 2022
$2.2M
Electroencephalograph Guidance of Anesthesia to Alleviate Geriatric Syndromes (ENUH2AG050312 · NIA · WASHINGTON UNIVERSITY · PI AVIDAN, MICHAEL SIMON · 2014 to 2014
$483k
THE DEFAULT MODE NETWORK DURING THE PATHOGENESIS OF POSTOPERATIVE DELIRIUMR21AG052821 · NIA · WASHINGTON UNIVERSITY · PI PALANCA, BEN JULIAN · 2016 to 2017
$419k
NCATS NIH HHS KL2 TR000450NCATS NIH HHS KL2 TR002346NCATS NIH HHS UL1 TR000448NCATS NIH HHS UL1 TR002345NIA NIH HHS R01 AG057901NIA NIH HHS R21 AG052821NIA NIH HHS UH2 AG050312NIA NIH HHS UH3 AG050312NIGMS NIH HHS T32 GM108539
6 · The paper itself

Abstract

STUDY

objectivesDelirium is a postoperative complication accompanied by disturbances in attention, cognition, arousal, and psychomotor activity. Wrist actigraphy has been advocated to study inactivity and inferred sleep patterns during delirium. We hypothesized that altered patterns of motor activity or immobility, reflective of disordered sleep and wakefulness patterns, would serve as predictive markers of hypoactive postoperative delirium.

methodsEighty-four elderly surgical patients were classified into three groups based on the timing of hypoactive delirium following surgery: intact with no delirium throughout postoperative days (POD) 0-5 (n = 51), delirium during POD 0-1 (n = 24), and delirium during POD 2-5 (n = 13). Delirium was detected on daily Confusion Assessment Method evaluations and chart review. Actigraphy measures were calculated from accelerometry signals acquired on the first postoperative day (POD 0, 16:00-23:00) and night (POD 0, 23:00-POD 1, 06:00).

resultsActigraphy metrics showed substantial interpatient variability. Among the three patient groups, only those without delirium showed greater movement during the day compared to night and also fewer minutes of night immobility (

conclusionsEarly postoperative wrist actigraphy metrics that serve as markers of sleep and wakefulness offer limited capacity as sole predictors or markers of hypoactive delirium. CLINICAL

trial registrationRegistry: ClinicalTrials.gov; Title: Electroencephalography Guidance of Anesthesia to Alleviate Geriatric Syndromes (ENGAGES) Study; Identifier: NCT02241655; URL: https://clinicaltrials.gov/ct2/show/NCT02241655.

Indexed as

ActigraphyAgedDeliriumFemaleGeriatric AssessmentHumansMalePostoperative ComplicationsPredictive Value of TestsReproducibility of Resultsactigraphyanesthesiaarousalpostoperative deliriumsleepsurgery

Identifiers

PMID30621829
PMCPMC6329546
OpenAlexW2911004075

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.