Trial reportJournal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine2019
Poor Outcomes Among Patients With Chronic Obstructive Pulmonary Disease With Higher Risk for Undiagnosed Obstructive Sleep Apnea in the LOTT Cohort.
Trial report in Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05623709 (Health Outcomes Following Treatment With Continuous Positive Airway Pressure or Noninvasive Ventilation in Patients With Chronic Obstructive Pulmonary Disease and a Sleep Related Breathing Disorder), which is not on this map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Health Outcomes Following Treatment With Continuous Positive Airway Pressure or Noninvasive Ventilation in Patients With Chronic Obstructive Pulmonary Disease and a Sleep Related Breathing Disorder
Who cites it
23 citing papers in PubMed, 48 citations in OpenAlex.
- Precision Medicine in Overlap Syndrome (COPD-Obstructive Sleep Apnea): From Phenotypes and Endotypes to Treatable Traits.Advances in respiratory medicine · 2026Review
- Overlap Syndrome (COPD and OSA): A Treatable Trait for Triple Treatment?Pulmonary therapy · 2025Article
- The Risk Factors and Predictors of Chronic Obstructive Pulmonary Disease in Patients With Obstructive Sleep Apnea-Hypopnea Syndrome at Plateau.The clinical respiratory journal · 2025Article
- Dynamic Risk Status of OSA and Its Association with COPD Incidence and Progression to Oxygen Therapy: Insights from a US National Cohort.International journal of chronic obstructive pulmonary disease · 2025Article
- Knowledge and Attitudes Toward Obstructive Sleep Apnea Among Korean Pulmonologists: A Nationwide Survey.Cureus · 2024Article
- Assessment of Obstructive Sleep Apnea Among Patients With Chronic Obstructive Pulmonary Disease in Primary Care.Chronic obstructive pulmonary diseases (Miami, Fla.) · 2024Article
- Exploring the impact of OSA on short-term survival in patients with AECOPD admitted to the ICU.PloS one · 2024Article
- The Overlap Syndrome: A Combination of Chronic Obstructive Pulmonary Disease and Obstructive Sleep Apnea.Cureus · 2024Review
- Correlation Between Diaphragmatic Excursion and Exercise Tolerance Improvement Following Pulmonary Rehabilitation in Patients with Chronic Obstructive Pulmonary Disease-Obstructive Sleep Apnea Overlap Syndrome.International journal of chronic obstructive pulmonary disease · 2024Article
- The STOP-BANG score and lung function in a general population.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2024Article
- International Consensus Statement on Obstructive Sleep Apnea.International forum of allergy & rhinology · 2023Review
- A risk-predictive model for obstructive sleep apnea in patients with chronic obstructive pulmonary disease.Frontiers in neuroscience · 2023Article
- The Overlap Syndrome of Obstructive Sleep Apnea and Chronic Obstructive Pulmonary Disease: A Systematic Review.Biomedicines · 2022Review
- Review of the prevalence, pathogenesis and management of OSA-COPD overlap.Sleep & breathing = Schlaf & Atmung · 2022Review
- Predictors and outcomes of obstructive sleep apnea in patients with chronic obstructive pulmonary disease in China.BMC pulmonary medicine · 2022Observational
- A review of therapies for the overlap syndrome of obstructive sleep apnea and chronic obstructive pulmonary disease.FASEB bioAdvances · 2021Article
- Sleep in hospitalized patients with chronic obstructive pulmonary disease: an observational study.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2020Observational
- Sleep disordered breathing and chronic obstructive pulmonary disease: a narrative review on classification, pathophysiology and clinical outcomes.Journal of thoracic disease · 2020Review
- Treatment of severe stable COPD: the multidimensional approach of treatable traits.ERJ open research · 2020Review
- Moderate-to-Severe Obstructive Sleep Apnea and Cognitive Function Impairment in Patients with COPD.International journal of chronic obstructive pulmonary disease · 2020Article
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 1 country.
Funding
Abstract
STUDY
objectivesEvaluate consequences of intermediate to high risk of undiagnosed obstructive sleep apnea (OSA) among individuals with chronic obstructive pulmonary disease (COPD).
methodsUsing data from the Long Term Oxygen Treatment Trial (LOTT), we assessed OSA risk at study entry among patients with COPD. We compared outcomes among those at intermediate to high risk (modified STOP-BANG score ≥ 3) relative to low risk (score < 3) for OSA. We compared risk of mortality or first hospitalization with proportional hazard models, and incidence of COPD exacerbations using negative binomial regression. We adjusted analyses for demographics, body mass index, and comorbidities. Last, we compared St. George Respiratory Questionnaire and Quality of Well-Being Scale results between OSA risk groups.
resultsOf the 222 participants studied, 164 (74%) were at intermediate to high risk for OSA based on the modified STOP-BANG score. Relative to the 58 low-risk individuals, the adjusted hazard ratio of mortality or first hospitalization was 1.61 (95% confidence interval 1.01-2.58) for those at intermediate to high risk of OSA. Risk for OSA was also associated with increased frequency of COPD exacerbations (adjusted incidence rate ratio: 1.78, 95% confidence interval 1.10-2.89). Respiratory symptoms by St. George Respiratory Questionnaire were 5.5 points greater (
conclusionsAmong individuals with COPD, greater risk for undiagnosed OSA is associated with poor outcomes. Increased recognition and management of OSA in this group could improve outcomes.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.