ArticleMolecular brain2019
Artificial association of memory events by optogenetic stimulation of hippocampal CA3 cell ensembles.
Article in Molecular brain, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 49 citations in OpenAlex.
- Balancing Stability and Flow in Hippocampal Networks via Inductive Bias and Learned Symmetry Breaking.bioRxiv : the preprint server for biology · 2026Article
- Functional loss of PKMζ in the dorsal hippocampus potentiates the time-dependent increase in false contextual fear memory and impairs spatial recognition memory in mice.Frontiers in behavioral neuroscience · 2026Article
- Periaqueductal gray activates antipredatory neural responses in the amygdala of foraging rats.eLife · 2024Article
- Requirement for hippocampal CA3 NMDA receptors in artificial association of memory events stored in CA3 cell ensembles.Molecular brain · 2023Article
- Sevoflurane-induced amnesia is associated with inhibition of hippocampal cell ensemble activity after learning.Biology open · 2022Article
- A short-term memory trace persists for days in the mouse hippocampus.Communications biology · 2022Article
- Formation of False Context Fear Memory Is Regulated by Hypothalamic Corticotropin-Releasing Factor in Mice.International journal of molecular sciences · 2022Article
- The shallow cognitive map hypothesis: A hippocampal framework for thought disorder in schizophrenia.Schizophrenia (Heidelberg, Germany) · 2022Review
- Neuronal Ensembles Organize Activity to Generate Contextual Memory.Frontiers in behavioral neuroscience · 2022Review
- Complementary roles of differential medial entorhinal cortex inputs to the hippocampus for the formation and integration of temporal and contextual memory (Systems Neuroscience).The European journal of neuroscience · 2021Review
- Dimensions and mechanisms of memory organization.Neuron · 2021Review
- Article
- DeepLabStream enables closed-loop behavioral experiments using deep learning-based markerless, real-time posture detection.Communications biology · 2021Article
- Sevoflurane Increases Hippocampal Theta Oscillations and Impairs Memory Via TASK-3 Channels.Frontiers in pharmacology · 2021Article
- High-Frequency Stimulation of Ventral CA1 Neurons Reduces Amygdala Activity and Inhibits Fear.Frontiers in behavioral neuroscience · 2021Article
- Review
- New era of optogenetics: from the central to peripheral nervous system.Critical reviews in biochemistry and molecular biology · 2020Review
- Disinhibition-assisted long-term potentiation in the prefrontal-amygdala pathway via suppression of somatostatin-expressing interneurons.Neurophotonics · 2020Article
- Ultrastructure of light-activated axons following optogenetic stimulation to produce late-phase long-term potentiation.PloS one · 2020Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Previous gain-of-function studies using an optogenetic technique showed that manipulation of the hippocampal dentate gyrus or CA1 cell ensembles is important for memory reactivation and to generate synthetic or false memory. However, gain-of-function study manipulating CA3 cell ensembles has not been reported. The CA3 area of the hippocampus comprises a recurrent excitatory circuit, which is thought to be important for the generation of associations among the stored information within one brain region. We investigated whether the coincident firing of cell ensembles in one brain region, hippocampal CA3, associates distinct events. CA3 cell ensembles responding to context exploration and during contextual fear conditioning were labeled with channelrhodopsin-2 (ChR2)-mCherry. The synchronous activation of these ensembles induced freezing behavior in mice in a neutral context, in which a foot shock had never been delivered. The recall of this artificial associative fear memory was context specific. In vivo electrophysiological recordings showed that 20-Hz optical stimulation of ChR2-mCherry-expressing CA3 neurons, which is the same stimulation protocol used in behavioral experiment, induced long-term potentiation at CA3-CA3 synapses. Altogether, these results demonstrate that the synchronous activation of ensembles in one brain region, CA3 of the hippocampus, is sufficient for the association of distinct events. The results of our electrophysiology potentially suggest that this artificial association of memory events might be induced by the strengthening of synaptic efficacy between CA3 ensembles via recurrent circuit.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.