ArticleParticle and fibre toxicology2019
Multi-walled carbon nanotube oxidation dependent keratinocyte cytotoxicity and skin inflammation.
Article in Particle and fibre toxicology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 67 citations in OpenAlex.
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- Examining the immunomodulatory role of nanoparticles on mast cell activation.Scientific reports · 2026Article
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- Energy Metabolic Regulatory Materials Promote Wound Healing in Senescent Environment.Progress in molecular and subcellular biology · 2026Review
- Carbon Nanotubes in the Diagnosis and Treatment of Ovarian Cancer.Indian journal of microbiology · 2025Article
- Potential Penetration of Engineered Nanoparticles under Practical Use of Protective Clothing Fabrics.Journal of chemical health & safety · 2024Article
- Carbon nanotubes induce cytotoxicity and apoptosis through increasing protein levels of Bax and ROS in mouse skin fibroblasts.Research in pharmaceutical sciences · 2024Article
- Immunomodulatory effects of nanoparticles on dendritic cells in a model of allergic contact dermatitis: importance of PD-L2 expression.Scientific reports · 2023Article
- Immunomodulatory Effects of Nanoparticles on Dendritic Cells in a Model of Allergic Contact Dermatitis - Importance of PD-L2 Expression.Research square · 2023Article
- Bioinspired Hierarchical Carbon Structures as Potential Scaffolds for Wound Healing and Tissue Regeneration Applications.Nanomaterials (Basel, Switzerland) · 2023Article
- Effects of Multiwall Carbon Nanotubes on Premature Kidney Aging: Biochemical and Histological Analysis.Toxics · 2023Article
- Nano-Hybrid Ag@LCCs Systems with Potential Wound-Healing Properties.Materials (Basel, Switzerland) · 2023Article
- Cancer Targeting and Diagnosis: Recent Trends with Carbon Nanotubes.Nanomaterials (Basel, Switzerland) · 2022Review
- Toxicity of Carbon-Based Nanomaterials in the Human Lung: A Comparative In-Vitro Study.Tanaffos · 2022Article
- Nanomaterial-Based Therapy for Wound Healing.Nanomaterials (Basel, Switzerland) · 2022Review
- Biocompatibility of nanomaterials and their immunological properties.Biomedical materials (Bristol, England) · 2021Review
- Carbon Nanotubes: Smart Drug/Gene Delivery Carriers.International journal of nanomedicine · 2021Review
- The UVR Filter Octinoxate Modulates Aryl Hydrocarbon Receptor Signaling in Keratinocytes via Inhibition of CYP1A1 and CYP1B1.Toxicological sciences : an official journal of the Society of Toxicology · 2020Article
- Comparing in vitro cytotoxicity of graphite, short multi-walled carbon nanotubes, and long multi-walled carbon nanotubes.Environmental science and pollution research international · 2020Article
- Functionalized Carbon Nanostructures Versus Drug Resistance: Promising Scenarios in Cancer Treatment.Molecules (Basel, Switzerland) · 2020Review
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
backgroundThe effects of carbon nanotubes on skin toxicity have not been extensively studied; however, our lab has previously shown that a carboxylated multi-walled carbon nanotube (MWCNT) exacerbates the 2, 4-dinitrofluorobenzene induced contact hypersensitivity response in mice. Here we examine the role of carboxylation in MWCNT skin toxicity.
resultsMWCNTs were analyzed by transmission electron microscopy, zetasizer, and x-ray photoelectron spectroscopy to fully characterize the physical properties. Two MWCNTs with different levels of surface carboxylation were chosen for further testing. The MWCNTs with a high level of carboxylation displayed increased cytotoxicity in a HaCaT keratinocyte cell line, compared to the MWCNTs with intermediate levels of carboxylation. However, neither functionalized MWCNT increased the level of in vitro reactive oxygen species suggesting an alternative mechanism of cytotoxicity. Each MWCNT was tested in the contact hypersensitivity model, and only the MWCNTs with greater than 20% surface carboxylation exacerbated the ear swelling responses. Analysis of the skin after MWCNT exposure reveals that the same MWCNTs with a high level of carboxylation increase epidermal thickness, mast cell and basophil degranulation, and lead to increases in polymorphonuclear cell recruitment when co-administered with 2, 4-dinitrofluorobenzene.
conclusionsThe data presented here suggest that acute, topical application of low doses of MWCNTs can induce keratinocyte cytotoxicity and exacerbation of allergic skin conditions in a carboxylation dependent manner.
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