Evidence map›Paper›PMID 30621704›Full record

ArticleWorld journal of surgical oncology2019

Automatic thyroid nodule recognition and diagnosis in ultrasound imaging with the YOLOv2 neural network.

Lei Wang, Shujian Yang, Shan Yang, Cheng Zhao, Guangye Tian, Yuxiu Gao, Yongjian Chen, Yun Lu

Open access · goldAbstract readValidation Study
In one paragraph

Article in World journal of surgical oncology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
66citing papers in PubMed, 4 pooled it
16.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

66 citing papers in PubMed, 4 syntheses or guidelines pooled it, 166 citations in OpenAlex.

  1. Pooled it
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  3. A comparison of artificial intelligence versus radiologists in the diagnosis of thyroid nodules using ultrasonography: a systematic review and meta-analysis.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2022
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6 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Lei WangDepartment of Gastrointestinal Surgery, The Affiliated Hospital of Qingdao University, No. 1677 Wutaishan Street, Qingdao, 266555, Shandong Province, China.
Shujian YangDepartment of Gastrointestinal Surgery, The Affiliated Hospital of Qingdao University, No. 1677 Wutaishan Street, Qingdao, 266555, Shandong Province, China.
Shan YangHisense Medical Equipment Co. Ltd, 399 Rd. Songling, Dist. Laoshan, Qingdao, 266000, Shandong Province, China.
Cheng ZhaoDepartment of Ultrasound, The Affiliated Hospital of Qingdao University, No. 1677 Wutaishan Street, Qingdao, 266555, Shandong Province, China.
Guangye TianHisense Medical Equipment Co. Ltd, 399 Rd. Songling, Dist. Laoshan, Qingdao, 266000, Shandong Province, China.
Yuxiu GaoDepartment of Ultrasound, The Affiliated Hospital of Qingdao University, No. 1677 Wutaishan Street, Qingdao, 266555, Shandong Province, China.
Yongjian ChenHisense Medical Equipment Co. Ltd, 399 Rd. Songling, Dist. Laoshan, Qingdao, 266000, Shandong Province, China.
Yun LuDepartment of Gastrointestinal Surgery, The Affiliated Hospital of Qingdao University, No. 1677 Wutaishan Street, Qingdao, 266555, Shandong Province, China. cloudylucn@126.com.
Affiliated Hospital of Qingdao University · CNHisense (China) · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIn this study, images of 2450 benign thyroid nodules and 2557 malignant thyroid nodules were collected and labeled, and an automatic image recognition and diagnosis system was established by deep learning using the YOLOv2 neural network. The performance of the system in the diagnosis of thyroid nodules was evaluated, and the application value of artificial intelligence in clinical practice was investigated.

methodsThe ultrasound images of 276 patients were retrospectively selected. The diagnoses of the radiologists were determined according to the Thyroid Imaging Reporting and Data System; the images were automatically recognized and diagnosed by the established artificial intelligence system. Pathological diagnosis was the gold standard for the final diagnosis. The performances of the established system and the radiologists in diagnosing the benign and malignant thyroid nodules were compared.

resultsThe artificial intelligence diagnosis system correctly identified the lesion area, with an area under the receiver operating characteristic (ROC) curve of 0.902, which is higher than that of the radiologists (0.859). This finding indicates a higher diagnostic accuracy (p = 0.0434). The sensitivity, positive predictive value, negative predictive value, and accuracy of the artificial intelligence diagnosis system for the diagnosis of malignant thyroid nodules were 90.5%, 95.22%, 80.99%, and 90.31%, respectively, and the performance did not significantly differ from that of the radiologists (p > 0.05). The artificial intelligence diagnosis system had a higher specificity (89.91% vs 77.98%, p = 0.026).

conclusionsCompared with the performance of experienced radiologists, the artificial intelligence system has comparable sensitivity and accuracy for the diagnosis of malignant thyroid nodules and better diagnostic ability for benign thyroid nodules. As an auxiliary tool, this artificial intelligence diagnosis system can provide radiologists with sufficient assistance in the diagnosis of benign and malignant thyroid nodules.

Indexed as

Neural Networks, ComputerAdultAgedDiagnosis, DifferentialFemaleHumansImage Interpretation, Computer-AssistedMaleMiddle AgedPredictive Value of TestsPrognosisRetrospective StudiesROC CurveThyroid GlandThyroid NoduleUltrasonographyArtificial intelligenceComputer-aided diagnosis systemsThyroid nodulesUltrasoundYOLOv2 neural network

Identifiers

PMID30621704
PMCPMC6325802
OpenAlexW2910443141

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.