ArticleLipids in health and disease2019
Non-traditional lipid profiles associated with ischemic stroke not hemorrhagic stroke in hypertensive patients: results from an 8.4 years follow-up study.
Article in Lipids in health and disease, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 3 of them syntheses that pooled it.
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Who cites it
19 citing papers in PubMed, 3 syntheses or guidelines pooled it, 40 citations in OpenAlex.
- Relationship between serum lipids and the risk of hemorrhagic stroke: a meta-analysis of 50 million participants from prospective cohort studies.Lipids in health and disease · 2025Pooled it
- Low-Density Lipoprotein Cholesterol Reductions of not Less Than 60 mg/dL Prevent Hemorrhagic Stroke in Hypertensive Populations: A Meta-analysis.Reviews in cardiovascular medicine · 2025Pooled it
- Low-Density Lipoprotein Cholesterol and Risk of Hemorrhagic Stroke: a Systematic Review and Dose-Response Meta-analysis of Prospective Studies.Current atherosclerosis reports · 2019Pooled it
- Incidence and predictors of stroke among hypertension patients in Awi Zone public hospitals, Northwest Ethiopia: Retrospective follow-up study.BMC cardiovascular disorders · 2026Article
- Association between LDL-C/HDL-C ratio and first stroke in hypertensive patients: a prospective cohort study.Frontiers in endocrinology · 2025Article
- Non-traditional lipid parameters are independent predictors of the location, distribution, and stroke events of moderate-to-severe intracranial and extracranial atherosclerotic stenosis.Frontiers in neurology · 2025Article
- Association of classic cardiovascular risk factors with myocardial infarction and ischemic stroke: A cross sectional analysis of the Shiraz Heart Study.International journal of cardiology. Cardiovascular risk and prevention · 2024Article
- Association of novel lipid indices with the white matter hyperintensities in cerebral small vessel disease: a cross-sectional study.Lipids in health and disease · 2024Article
- A nonlinear relationship between the triglycerides to high-density lipoprotein cholesterol ratio and stroke risk: an analysis based on data from the China Health and Retirement Longitudinal Study.Diabetology & metabolic syndrome · 2024Article
- A non-linear connection between the total cholesterol to high-density lipoprotein cholesterol ratio and stroke risk: a retrospective cohort study from the China Health and Retirement Longitudinal Study.European journal of medical research · 2024Article
- Association of Dilated Perivascular Spaces With Lipid Indices in Ischemic Stroke Patients.Cureus · 2022Article
- Association between four nontraditional lipids and ischemic stroke: a cohort study in Shanghai, China.Lipids in health and disease · 2022Article
- Review
- Article
- The Impact of Sex and Gender on Stroke.Circulation research · 2022Review
- Article
- Lipids and Lipid Mediators Associated with the Risk and Pathology of Ischemic Stroke.International journal of molecular sciences · 2020Review
- Association of LDL-C/HDL-C Ratio With Stroke Outcomes Within 1 Year After Onset: A Hospital-Based Follow-Up Study.Frontiers in neurology · 2020Article
- Blood pressure predictors of stroke in rural Chinese dwellers with hypertension: a large-scale prospective cohort study.BMC cardiovascular disorders · 2019Article
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
backgroundStudies have shown that non-traditional lipid profiles have a better association with stroke than traditional blood lipids in clinical applications, other studies have drawn different conclusions.
methodsThis study was a large-scale study with a median follow-up of 8.4 years. The hazard ratio (HR) and 95% Confidence interval (CI) of lipid variables for risk of incident stroke were analyzed by multivariable Cox proportional hazard models.
resultsDuring the follow-up, 502 new strokes (310 ischemic, 187 hemorrhagic, and 5 unclassified strokes) occurred among the 5099 hypertensive patients. Comparing with the lowest quarter, the HR of future ischemic stroke (IS) in the highest were 1.41(95%CI, 1.03-1.92) for TC, 1.60 (95%CI, 1.15-2.22) for TG, 1.03 (95%CI, 0.75-1.42) for HDL-C, 1.77 (95%CI, 1.29-2.44) for LDL-C, 1.42 (95%CI, 1.03-1.94) for non-HDL, 2.09 (95%CI, 1.45-3.00) for TC/HDL, 2.08 (95%CI, 1.46-2.96) for LDL/HDL, 1.86 (95%CI 1.33-2.60) for TG/HDL, respectively. No significant association was observed between lipid-related indicators and hemorrhagic stroke. The results of statistical differences showed that the correlation between LDL/HDL and the risk of ischemic stroke in non-traditional lipids was higher than that of other traditional lipids (P < 0.001), except for LDL (P = 0.056).
conclusionsWe didn't find that HDL was associated with the risk of stroke and all the lipid parameters were not associated with the risk of hemorrhagic stroke. LDL/HDL was associated with a higher risk of ischemic stroke than other lipids and should be considered for clinical diagnosis and future disease prevention.
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