ArticleRespiratory research2019
Gasometric gradients between blood obtained from the pulmonary artery wedge and pulmonary artery positions in pulmonary arterial hypertension.
Article in Respiratory research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 8 citations in OpenAlex.
- Cardiac Output During Exercise: Thermodilution Versus Direct Fick.Journal of the American Heart Association · 2026Article
- Significance of Hypocapnia in the Risk Assessment of Patients with Pulmonary Hypertension.Journal of clinical medicine · 2023Article
- Reply: Will the Real Pulmonary Pressure Please Stand Up?Annals of the American Thoracic Society · 2020Article
- Unexpected values of mixed venous blood analysis: Back to basics before sampling.Journal of anaesthesiology, clinical pharmacologyArticle
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
introductionLittle is known on the pulmonary gradients of oxyhemoglobin, carboxyhemoglobin and methemoglobin in pulmonary arterial hypertension (PAH). We sought to determine these gradients in group 1 PAH and assess their association with disease severity and survival.
methodsDuring right heart catheterization (RHC) we obtained blood from pulmonary artery (PA) and pulmonary artery wedge (PAW) positions and used co-oximetry to test their gasometric differences.
resultsWe included a total of 130 patients, 65 had group 1 PAH, 40 had pulmonary hypertension (PH) from groups 2-5 and 25 had no PH during RHC. In all groups, PAW blood had higher pH, carboxyhemoglobin and lactate as well as lower pCO
conclusionsMarked differences were observed in the gasometric determinations between PAW and PA blood. The pulmonary gradient of methemoglobin was lower in PAH patients compared to controls and a higher PAW blood methemoglobin was associated with a more pronounced pulmonary vascular response to inhaled nitric oxide. Pulmonary artery and PAW oxyhemoglobin tracked with disease severity and survival in PAH.
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