ArticleBMC pregnancy and childbirth2019
Non-additive effects of ACVR2A in preeclampsia in a Philippine population.
Article in BMC pregnancy and childbirth, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.
- Nutrigenetic Investigations in Preeclampsia.Nutrients · 2024Pooled it
- Variations in Eclampsia Risk Across Asian Origin Groups in the United States.Maternal and child health journal · 2026Article
- Disparities in maternal and fetal health among ethnogeographic groups-a retrospective cohort study of 30,000 women from a middle eastern multiethnic maternity population.Frontiers in global women's health · 2026Article
- Exploring the association between STOX1:p.(Tyr153His) variant and preeclampsia risk in Egyptian women.Scientific reports · 2025Article
- ACVR2A facilitates trophoblast cell invasion through TCF7/c-JUN pathway in pre-eclampsia progression.eLife · 2025Article
- Association between rs1799724 of TNF- α gene and early onset preeclampsia in Chinese: A pilot study.European journal of obstetrics & gynecology and reproductive biology: X · 2024Article
- Prevalence and risk factors associated with severe pre-eclampsia among postpartum women in Zanzibar: a cross-sectional study.BMC public health · 2020Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundMultiple interrelated pathways contribute to the pathogenesis of preeclampsia, and variants in susceptibility genes may play a role among Filipinos, an ethnically distinct group with high prevalence of the disease. The objective of this study was to examine the association between variants in maternal candidate genes and the development of preeclampsia in a Philippine population.
methodsA case-control study involving 29 single nucleotide polymorphisms (SNPs) in 21 candidate genes was conducted in 150 patients with preeclampsia (cases) and 175 women with uncomplicated normal pregnancies (controls). Genotyping for the GRK4 and DRD1 gene variants was carried out using the TaqMan Assay, and all other variants were assayed using the Sequenom MassARRAY Iplex Platform. PLINK was used for SNP association testing. Multilocus association analysis was performed using multifactor dimensionality reduction (MDR) analysis.
resultsAmong the clinical factors, older age (P < 1 × 10-4), higher BMI (P < 1 × 10-4), having a new partner (P = 0.006), and increased time interval from previous pregnancy (P = 0.018) associated with preeclampsia. The MDR algorithm identified the genetic variant ACVR2A rs1014064 as interacting with age and BMI in association with preeclampsia among Filipino women.
conclusionsThe MDR algorithm identified an interaction between age, BMI and ACVR2A rs1014064, indicating that context among genetic variants and demographic/clinical factors may be crucial to understanding the pathogenesis of preeclampsia among Filipino women.
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