Evidence map›Paper›PMID 30621529›Full record

Trial reportStroke2019

Safety of Carotid Revascularization in Patients With a History of Coronary Heart Disease.

Eline J Volkers, Ale Algra, L Jaap Kappelle, Jean-Pierre Becquemin, Gert J de Borst, Martin M Brown, Richard Bulbulia, David Calvet, Hans-Henning Eckstein, Gustav Fraedrich and 12 more

Open access · hybridAbstract readComparative StudyMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Stroke, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 14 institutions in 7 countries.

Eline J VolkersFrom the Department of Neurology and Neurosurgery, Brain Center Rudolf Magnus (E.J.V., A.A., L.J.K.), University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.
Ale AlgraFrom the Department of Neurology and Neurosurgery, Brain Center Rudolf Magnus (E.J.V., A.A., L.J.K.), University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.
L Jaap KappelleFrom the Department of Neurology and Neurosurgery, Brain Center Rudolf Magnus (E.J.V., A.A., L.J.K.), University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.
Jean-Pierre BecqueminIVPE, Hopital Privé Paul D'Egine, Champigny, France (J.-P.B.).
Gert J de BorstDepartment of Vascular Surgery (G.J.d.B.), University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.
Martin M BrownDepartment of Brain Repair and Rehabilitation, UCL Institute of Neurology, University College London, United Kingdom (M.M.B., L.H.B.).
Richard BulbuliaMRC Population Health Research Unit, Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, United Kingdom (R.B.).
David CalvetDepartment of Neurology, Hôpital Sainte-Anne, Université Paris-Descartes, DHU Neurovasc Sorbonne Paris Cité, INSERM U894, Paris, France (D.C., J.-L.M.).
Hans-Henning EcksteinDepartment of Vascular and Endovascular Surgery/Vascular Center, Klinikum rechts der Isar, Technical University Munich, Germany (H.-H.E.).
Gustav FraedrichDepartment of Vascular Surgery, Medical University of Innsbruck, Austria (G.F.).
John GregsonDepartment of Medical Statistics, London School for Hygiene and Tropical Medicine, United Kingdom (J.G.).
Alison HallidayNuffield Department of Surgical Sciences, John Radcliffe Hospital, Oxford, United Kingdom (A.H.).
Jeroen HendrikseDepartment of Radiology (J.H.), University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.
George HowardDepartment of Biostatistics, UAB School of Public Health, Birmingham, AL (G.H.).
Olav JansenClinic for Radiology and Neuroradiology, UKSH Campus Kiel, Germany (O.J.).
Gary S RoubinCardiovascular Associates of the Southeast, Birmingham, AL (G.S.R.).
Leo H BonatiDepartment of Brain Repair and Rehabilitation, UCL Institute of Neurology, University College London, United Kingdom (M.M.B., L.H.B.).
Thomas G BrottDepartment of Neurology, Mayo Clinic, Jacksonville, FL (T.G.B.).
Jean-Louis MasDepartment of Neurology, Hôpital Sainte-Anne, Université Paris-Descartes, DHU Neurovasc Sorbonne Paris Cité, INSERM U894, Paris, France (D.C., J.-L.M.).
Peter A RinglebDepartment of Neurology, University of Heidelberg Medical School, Germany (P.A.R.).
Jacoba P GrevingJulius Center for Health Sciences and Primary Care (E.J.V., A.A., J.P.G.), University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.
Carotid Stenosis Trialists’ Collaboration
University Medical Center Utrecht · NLSorbonne Paris Cité · FRUniversity College London · GBUtrecht University · NLAlabama Department of Public Health · USCardiovascular Research Associates · USHôpital Privé Jacques Cartier · FRJohn Radcliffe Hospital · GBKlinikum rechts der Isar · DEMayo Clinic in Florida · USUniversität Innsbruck · ATUniversity Hospital Heidelberg · DEUniversity of Lübeck · DEUniversity of Oxford · GB

Funding

CREST-2 Clinical Coordinating CenterU01NS080168 · NINDS · MAYO CLINIC JACKSONVILLE · PI Thomas G Brott, JAMES F MESCHIA · 2014 to 2026
$56.3M
Medical Research Council G0300411NINDS NIH HHS U01 NS080168
6 · The paper itself

Abstract

Background and Purpose- We investigated whether procedural stroke or death risk of carotid artery stenting (CAS) compared with carotid endarterectomy (CEA) is different in patients with and without history of coronary heart disease (CHD) and whether the treatment-specific impact of age differs. Methods- We combined individual patient data of 4754 patients with symptomatic carotid stenosis from 4 randomized trials (EVA-3S [Endarterectomy Versus Angioplasty in Patients With Symptomatic Severe Carotid Stenosis], SPACE [Stent-Protected Angioplasty Versus Carotid Endarterectomy], ICSS [International Carotid Stenting Study], and CREST [Carotid Revascularization Endarterectomy Versus Stenting Trial]). Procedural risk was defined as any stroke or death ≤30 days after treatment. We compared procedural risk between both treatments with Cox regression analysis, stratified by history of CHD and age (<70, 70-74, ≥75 years). History of CHD included myocardial infarction, angina, or coronary revascularization. Results- One thousand two hundred ninety-three (28%) patients had history of CHD. Procedural stroke or death risk was higher in patients with history of CHD. Procedural risk in patients treated with CAS compared with CEA was consistent in patients with history of CHD (8.3% versus 4.6%; hazard ratio [HR], 1.96; 95% CI, 0.67-5.73) and in those without (6.9% versus 3.6%; HR, 1.93; 95% CI, 1.40-2.65; P

Indexed as

Carotid StenosisCoronary DiseaseStrokeAgedCarotid ArteriesCerebral RevascularizationDisease-Free SurvivalEndarterectomy, CarotidFemaleHumansMaleMiddle AgedPostoperative ComplicationsRisk FactorsSafetySurvival Rateangioplastycarotid stenosiscoronary artery diseaseendarterectomyrisk

Identifiers

PMID30621529
PMCPMC6358179
OpenAlexW2908649025

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.